The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis
DC Field | Value | Language |
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dc.contributor.author | Lim, Do-Hwan | - |
dc.contributor.author | Oh, Chun-Taek | - |
dc.contributor.author | Lee, Langho | - |
dc.contributor.author | Hong, Jae-Sang | - |
dc.contributor.author | Noh, Su-Hyun | - |
dc.contributor.author | Hwang, Seungwoo | - |
dc.contributor.author | Kim, Sungchan | - |
dc.contributor.author | Han, Sung-Jun | - |
dc.contributor.author | Lee, Young Sik | - |
dc.date.accessioned | 2021-09-07T07:37:03Z | - |
dc.date.available | 2021-09-07T07:37:03Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-10-03 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111395 | - |
dc.description.abstract | Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a >= 1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | RNA PATHWAY | - |
dc.subject | DISTINCT ROLES | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | DICER-2 | - |
dc.subject | GENE | - |
dc.subject | LONGEVITY | - |
dc.subject | VIRUSES | - |
dc.subject | DEFENSE | - |
dc.subject | INSULIN | - |
dc.subject | BIND | - |
dc.title | The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jae-Sang | - |
dc.contributor.affiliatedAuthor | Lee, Young Sik | - |
dc.identifier.doi | 10.1016/j.febslet.2011.08.034 | - |
dc.identifier.scopusid | 2-s2.0-80053240762 | - |
dc.identifier.wosid | 000295473600024 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.19, pp.3079 - 3085 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 3079 | - |
dc.citation.endPage | 3085 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | RNA PATHWAY | - |
dc.subject.keywordPlus | DISTINCT ROLES | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | DICER-2 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | VIRUSES | - |
dc.subject.keywordPlus | DEFENSE | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | BIND | - |
dc.subject.keywordAuthor | Endogenous siRNA | - |
dc.subject.keywordAuthor | Dicer-2 | - |
dc.subject.keywordAuthor | Stress response | - |
dc.subject.keywordAuthor | Lifespan | - |
dc.subject.keywordAuthor | Metabolic homeostasis | - |
dc.subject.keywordAuthor | Drosophila | - |
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