Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-kappa B pathways in monocytes/macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Young-Jun | - |
dc.contributor.author | Kang, Byeong-Ho | - |
dc.contributor.author | Jeon, Hye-Sook | - |
dc.contributor.author | Park, In-Sun | - |
dc.contributor.author | Lee, Ki-Up | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Park, Gil-Hong | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Schedin, Pepper | - |
dc.contributor.author | Min, Bon-Hong | - |
dc.date.accessioned | 2021-09-07T07:41:07Z | - |
dc.date.available | 2021-09-07T07:41:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111419 | - |
dc.description.abstract | Most solid tumor tissues possess a significant population of macrophages, which are known to be closely linked with tumor progression and metastasis. Clusterin has been reported to be overexpressed in various tumors and to have a tumor-promoting role. As clusterin induction and macrophage infiltration occur concurrently at the tumor site, it raises a possibility that clusterin may regulate the function of macrophages via facilitating ECM remodeling. Here, we demonstrate for the first time the expression of MMP-9 by clusterin in human primary monocytes as well as human and murine macrophage cell lines, THP-1, and Raw264.7. MMP-9 expression was accompanied by increased enzymatic activity, as revealed by gelatin zymography. The MMP-9 activity promoted by clusterin was found to be dependent on the activation of ERK1/2 and PI3K/Akt but not p38 or JNK pathways. Inhibition of PI3K activity did not affect the activation of ERK1/2 and vice versa, indicating that the two pathways were independently operated to stimulate MMP-9 activity. Moreover, clusterin facilitated nuclear translocation of NF-kappa B p65 along with I kappa B-alpha degradation and phosphorylation, which was critical for MMP-9 expression. As NF-kappa B is a central regulator of inflammation, clusterin may provide a molecular link between inflammation and cancer via up-regulating NF-kappa B and MMP-9. Collectively, these data highlight a novel role of clusterin as a stimulator for MMP-9 expression in macrophages, which may contribute to the tissue reorganization by serving as a modulator for ECM degradation. J. Leukoc. Biol. 90: 761-769; 2011. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | KAPPA-B PATHWAY | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CANCER | - |
dc.subject | PROGRESSION | - |
dc.subject | PROSTATE | - |
dc.subject | MYOCARDITIS | - |
dc.subject | THERAPY | - |
dc.subject | CARCINOGENESIS | - |
dc.title | Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-kappa B pathways in monocytes/macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Young-Jun | - |
dc.contributor.affiliatedAuthor | Park, Gil-Hong | - |
dc.contributor.affiliatedAuthor | Min, Bon-Hong | - |
dc.identifier.doi | 10.1189/jlb.0311110 | - |
dc.identifier.scopusid | 2-s2.0-80053345559 | - |
dc.identifier.wosid | 000295372100016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.90, no.4, pp.761 - 769 | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 90 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 761 | - |
dc.citation.endPage | 769 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | KAPPA-B PATHWAY | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | PROSTATE | - |
dc.subject.keywordPlus | MYOCARDITIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | glycosylation | - |
dc.subject.keywordAuthor | ECM remodeling | - |
dc.subject.keywordAuthor | tumor invasion | - |
dc.subject.keywordAuthor | inflammation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.