PAI-1 expression and its regulation by promoter 4G/5G polymorphism in clear cell renal cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Choi, Jung-Woo | - |
dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Park, Hong Seok | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.date.accessioned | 2021-09-07T07:57:08Z | - |
dc.date.available | 2021-09-07T07:57:08Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111507 | - |
dc.description.abstract | Aims To characterise patients with high plasminogen activator inhibitor-1 (PAI-1) expression as oral PAI-1 antagonists are currently in preclinical trials, and to determine whether the PAI-1 promoter 4G/5G polymorphism regulates PAI-1 expression in clear cell renal cell carcinoma (CCRCC). Methods PAI-1 expression was examined by immunohistochemistry in 69 CCRCC specimens. In addition, the promoter 4G/5G polymorphism was investigated by both allele-specific PCR and direct DNA sequencing. Results PAI-1 was overexpressed in 25/69 (36.2%) patients with CCRCC. PAI-1 staining was intense in tumour cells with a high Fuhrman nuclear grade and in spindle-shaped tumour cells. PAI-1 expression was significantly associated with older age at diagnosis (p = 0.027), high nuclear grade (p < 0.001), advanced clinical stage (p = 0.030) and distant metastasis (p = 0.009). In survival analyses, PAI-1 expression was correlated with disease-free survival in Kaplan-Meier curves (p = 0.015) but was not significant in the Cox hazards model (p = 0.527). The frequencies of the promoter polymorphism were 24.6% (17/69) 4G/4G, 43.5% (30/69) 4G/5G and 31.9% (22/69) 5G/5G. The homozygous 4G/4G or 5G/5G group showed a tendency for a high nuclear grade (p = 0.05) but the 4G/5G polymorphism was not related to other prognostic parameters. PAI-1 expression was poorly correlated with its promoter 4G/5G polymorphism (Spearman rho = 0.088). Conclusions CCRCC with high PAI-1 expression is characterised by older age, high nuclear grade, advanced stage, distant metastasis and/or shortened disease-free survival. PAI-1 expression is not affected by the promoter 4G/5G polymorphism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | B M J PUBLISHING GROUP | - |
dc.subject | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | CLINICAL-SIGNIFICANCE | - |
dc.subject | COLORECTAL-CANCER | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | PROGNOSTIC VALUE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | GENE PROMOTER | - |
dc.subject | BINDING | - |
dc.subject | TRANSITION | - |
dc.title | PAI-1 expression and its regulation by promoter 4G/5G polymorphism in clear cell renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jung-Woo | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Han | - |
dc.contributor.affiliatedAuthor | Park, Hong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.identifier.doi | 10.1136/jclinpath-2011-200182 | - |
dc.identifier.scopusid | 2-s2.0-80053192295 | - |
dc.identifier.wosid | 000295118300012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PATHOLOGY, v.64, no.10, pp.893 - 897 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PATHOLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL PATHOLOGY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 893 | - |
dc.citation.endPage | 897 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | GENE PROMOTER | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | TRANSITION | - |
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