Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Ha-reum | - |
dc.contributor.author | Yoon, Sun Young | - |
dc.contributor.author | Song, Seok Bean | - |
dc.contributor.author | Park, Yoorim | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Kim, Seonghan | - |
dc.contributor.author | Hur, Dae Young | - |
dc.contributor.author | Song, Hyun Keun | - |
dc.contributor.author | Park, Hyunjeong | - |
dc.contributor.author | Cho, Daeho | - |
dc.date.accessioned | 2021-09-07T08:01:29Z | - |
dc.date.available | 2021-09-07T08:01:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0171-2985 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111531 | - |
dc.description.abstract | Thymosin beta 4 (T beta 4) is the major G-actin sequestering molecule and is abundant in lymphoid tissues. However, it is not clear what regulates T beta 4 expression and what its function is on natural killer (NK) cells. We investigated whether interleukin-18 (IL-18) has a role in T beta 4 expression and if enhanced T beta 4 influences IL-18-mediated interferon-gamma (IFN-gamma) secretion. In this study, recombinant human IL-18 (rhIL-18) enhanced the endogenous level of T beta 4 through p38MAPK and JNK signaling pathway in the human NK cell line, NK-92MI. Overexpression of endogeneous T beta 4 stimulated IFN-gamma expression and secretion. Additionally, pretreatment with an inhibitor for T beta 4 decreased IL-18-enhanced IFN-gamma secretion, and transfection with T beta 4-specific short hairpin RNA resulted in reduction of IFN-gamma production in primary NK cells as well as in the human NK cell line. Taken together, these data indicated that T beta 4 is regulated by IL-18 and is involved in IL-18-enhanced IFN-gamma secretion in NK cells. (c) 2011 Elsevier GmbH. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | IFN-GAMMA | - |
dc.subject | ACTIN CYTOSKELETON | - |
dc.subject | PROINFLAMMATORY CYTOKINE | - |
dc.subject | INFLAMMATORY MEDIATORS | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | GENE-TRANSFER | - |
dc.subject | T-CELLS | - |
dc.subject | ACTIVATION | - |
dc.subject | INNATE | - |
dc.title | Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.imbio.2011.04.002 | - |
dc.identifier.scopusid | 2-s2.0-80052100986 | - |
dc.identifier.wosid | 000296365700012 | - |
dc.identifier.bibliographicCitation | IMMUNOBIOLOGY, v.216, no.10, pp.1155 - 1162 | - |
dc.relation.isPartOf | IMMUNOBIOLOGY | - |
dc.citation.title | IMMUNOBIOLOGY | - |
dc.citation.volume | 216 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1155 | - |
dc.citation.endPage | 1162 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | ACTIN CYTOSKELETON | - |
dc.subject.keywordPlus | PROINFLAMMATORY CYTOKINE | - |
dc.subject.keywordPlus | INFLAMMATORY MEDIATORS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | GENE-TRANSFER | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordAuthor | Interleukin-18 | - |
dc.subject.keywordAuthor | Natural killer cells | - |
dc.subject.keywordAuthor | Thymosin beta 4 | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
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