Changes in the arginine methylation of organ proteins during the development of diabetes mellitus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jong Hoon | - |
dc.contributor.author | Park, Gil Hong | - |
dc.contributor.author | Lee, Young Koo | - |
dc.contributor.author | Park, Jun Hyung | - |
dc.date.accessioned | 2021-09-07T08:02:01Z | - |
dc.date.available | 2021-09-07T08:02:01Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111534 | - |
dc.description.abstract | Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52 kDa in liver tissue and at 38 and 25 kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | DIMETHYLARGININE DIMETHYLAMINOHYDROLASE | - |
dc.subject | ASYMMETRIC DIMETHYLARGININE | - |
dc.subject | ENDOGENOUS INHIBITOR | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | RATS | - |
dc.subject | METABOLISM | - |
dc.subject | EXPRESSION | - |
dc.subject | DISEASE | - |
dc.subject | MOUSE | - |
dc.title | Changes in the arginine methylation of organ proteins during the development of diabetes mellitus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Gil Hong | - |
dc.identifier.doi | 10.1016/j.diabres.2011.07.005 | - |
dc.identifier.scopusid | 2-s2.0-80054883738 | - |
dc.identifier.wosid | 000296529100024 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, v.94, no.1, pp.111 - 118 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.title | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.citation.volume | 94 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 118 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | DIMETHYLARGININE DIMETHYLAMINOHYDROLASE | - |
dc.subject.keywordPlus | ASYMMETRIC DIMETHYLARGININE | - |
dc.subject.keywordPlus | ENDOGENOUS INHIBITOR | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Arginine methylation | - |
dc.subject.keywordAuthor | Asymmetric dimethylarginine | - |
dc.subject.keywordAuthor | Dimethylarginine dimethylaminohydrolase | - |
dc.subject.keywordAuthor | Nitric oxide synthase | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.