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Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system
- Issue Date
- 28-9월-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Flow chemistry; Micromixer; Palladium; Diaryl alkynes; Decarboxylative coupling
- Citation
- TETRAHEDRON LETTERS, v.52, no.39, pp.5064 - 5067
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 52
- Number
- 39
- Start Page
- 5064
- End Page
- 5067
- ISSN
- 0040-4039
- Abstract
- Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction. (C) 2011 Elsevier Ltd. All rights reserved.
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