Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Do, Hyun Joo | - |
dc.contributor.author | Chung, Hye Kyung | - |
dc.contributor.author | Moon, Jiyoung | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.date.accessioned | 2021-09-07T08:36:15Z | - |
dc.date.available | 2021-09-07T08:36:15Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-09-01 | - |
dc.identifier.issn | 0912-0009 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111605 | - |
dc.description.abstract | In the present study, we evaluated the relationships of estimated desaturase activities with cardiometabolic risk factors including abdominal obesity, atherogenic lipoprotein phenotype and inflammation in Koreans. Ninety-three healthy volunteers participated in this cross-sectional study. LDL particle size was determined using gradient gel electrophoresis and inflammatory markers including C-reactive protein, soluble intercellular adhesion molecule-1, and adiponectin were measured. Stearoyl-coA desaturase, delta-6 desaturase and delta-5 desaturase were estimated as precursor to fatty acid ratios. The results showed that stearoyl-coA desaturase was correlated with body mass index (r = 0.235, p<0.05), triglyceride (r = 0.261, p<0.001), and HDL-cholesterol (r = 0.226, p<0.05). Stearoyl-coA desaturase was associated with only triglyceride (r = 0.283, p<0.01). Delta-6 desaturase was correlated with body mass index (r = 0.236, p<0.05), waist circumference (r = 0.218, p<0.05), triglyceride (r = 0.399, p<0.001), C-reactive protein (r = 0.333, p<0.001), soluble intercellular adhesion molecule-1 (r = 0.229, p<0.05), HDL-cholesterol (r = -0.325, p<0.01), LDL particle size (r = -0.297, p<0.01) and adiponectin (r = -0.233, p<0.05). In contrast, delta-5 desaturase was correlated with body mass index (r = -0.324, p<0.01), waist circumference (r = -0.276, p<0.01), triglyceride (r = -0.329, p<0.01), C-reactive protein (r = -0.215, p<0.05), HDL-cholesterol (r = 0.262, p<0.05) and LDL particle size (r = 0.278, p<0.01). Stepwise multiple regression analysis revealed that delta-6 desaturase (p<0.01) together with waist circumference (p<0.001) were found to be independent factors for determining plasma levels of C-reactive protein (R-2 = 0.230). Estimated desaturase activities are closely associated with the features of cardiometabolic risk in Koreans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION | - |
dc.subject | FATTY-ACID-COMPOSITION | - |
dc.subject | MIDDLE-AGED MEN | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | INSULIN SENSITIVITY | - |
dc.subject | GENE-TRANSCRIPTION | - |
dc.subject | SERUM-LIPIDS | - |
dc.subject | RISK-FACTORS | - |
dc.subject | INFLAMMATION | - |
dc.subject | ADOLESCENTS | - |
dc.title | Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.3164/jcbn.10-147 | - |
dc.identifier.scopusid | 2-s2.0-80052039827 | - |
dc.identifier.wosid | 000295063800011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, v.49, no.2, pp.131 - 135 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | - |
dc.citation.title | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 131 | - |
dc.citation.endPage | 135 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | FATTY-ACID-COMPOSITION | - |
dc.subject.keywordPlus | MIDDLE-AGED MEN | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | GENE-TRANSCRIPTION | - |
dc.subject.keywordPlus | SERUM-LIPIDS | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ADOLESCENTS | - |
dc.subject.keywordAuthor | desaturase | - |
dc.subject.keywordAuthor | fatty acid composition | - |
dc.subject.keywordAuthor | cardiometabolic risk factor | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | atherogenic dyslipidemia | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.