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Dose Pattern and Effectiveness of Paliperidone Extended-Release Tablets in Patients With Schizophrenia

Authors
Lee, Jung-SunAhn, Joon-HoLee, Jong-IlKim, Jong-HoonJung, InKwaLee, Chang-UkLee, Jun-YoungLee, Sang-IckKim, Chang-Yoon
Issue Date
9월-2011
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
schizophrenia; paliperidone extended release; effectiveness; early increase of the initial dose
Citation
CLINICAL NEUROPHARMACOLOGY, v.34, no.5, pp.186 - 190
Indexed
SCIE
SCOPUS
Journal Title
CLINICAL NEUROPHARMACOLOGY
Volume
34
Number
5
Start Page
186
End Page
190
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111652
DOI
10.1097/WNF.0b013e3182281c05
ISSN
0362-5664
Abstract
Objectives: The objectives of this 12-week multicenter, open-label, noncomparative study were to evaluate the overall effectiveness of paliperidone extended release (ER), the feasibility of maintaining patients on the initial dose of 6 mg, and the relationship between dose pattern and treatment response in schizophrenic patients with inadequate responses to initial treatment in a natural setting. Methods: All patients received 6 mg of paliperidone ER during the first 2 weeks, and subsequently, the dose was adjusted at each visit based on the patient response. We examined the response rate and the effectiveness of different dose patterns of paliperidone ER such as "early increase (dose increased to 9 mg at week 2),'' "late increase (dose increased to 9 mg at week 4),'' and "maintenance group.'' Results: The response rate based on the Clinical Global Impression of Improvement or Severity response criteria was 33.6% or 61.7%, respectively. The proportion of patients who stayed with the initial dose of 6 mg was 44.5% and the response rate of these patients was 79.8%. When the treatment response to the initial dose of 6 mg is inadequate (Clinical Global Impression of Improvement Q4 at week 2), an early increase in the dose seems to be more effective than maintenance or late increase of the initial dose. Conclusions: This study suggests that paliperidone ER may be an effective and well-tolerated antipsychotics in the treatment of patients with schizophrenia.
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