Obesity phenotype and cardiovascular changes
- Authors
- Park, Juri; Kim, Seong H.; Cho, Goo-Yeong; Baik, Inkyung; Kim, Nan H.; Lim, Hong E.; Kim, Eung J.; Park, Chang G.; Lim, Sang Y.; Kim, Yong H.; Kim, Hyun; Lee, Seung K.; Shin, Chol
- Issue Date
- 9월-2011
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- arterial stiffness; carotid intima-media thickness; echocardiography; left ventricle; metabolic syndrome; obesity
- Citation
- JOURNAL OF HYPERTENSION, v.29, no.9, pp.1765 - 1772
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HYPERTENSION
- Volume
- 29
- Number
- 9
- Start Page
- 1765
- End Page
- 1772
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111669
- DOI
- 10.1097/HJH.0b013e32834a50f3
- ISSN
- 0263-6352
- Abstract
- Objective Healthy obese phenotype with favorable metabolic profiles is proposed. However, whether healthy obesity leads to target organ changes is controversial. We investigated the impact of a healthy obesity on cardiovascular structure and function. Methods A total of 2540 participants without known cardiovascular disease were enrolled. According to BMI and the metabolic syndrome (MetS) component, the participants were divided into six groups: healthy (none of five MetS components) normal weight (BMI <23 kg/m(2)), unhealthy (one or more of five MetS components) normal weight, healthy overweight (BMI 23-24.9 kg/m(2)), unhealthy overweight, healthy obesity (BMI >= 25 kg/m(2)), and unhealthy obesity. The cardiovascular changes were assessed by echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV). Results In a multivariate analysis after adjusting for age, sex, heart rate, high-sensitivity C-reactive protein, and medication for hypertension and diabetes mellitus, the unhealthy overweight and obese groups showed statistically significant changes in the left ventricular mass index, mitral E/A ratio, E/Ea ratio, TDI Ea velocity, common carotid artery intima-media thickness (CCA-IMT), and brachial-ankle PWV (P<0.001), compared with the healthy normal weight individuals. In the healthy overweight and obese groups, CCA-IMT and brachial-ankle PWV values were similar, but left-ventricular mass index and TDI Ea velocity were significantly different (P<0.001). Conclusion Healthy obesity was associated with subtle changes in left ventricular structure and function. These data provide evidence that metabolically healthy phenotypes with excess weight may not be a benign condition. J Hypertens 29: 1765-1772 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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