Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase
DC Field | Value | Language |
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dc.contributor.author | Yoon, In-Soo | - |
dc.contributor.author | Chung, Ji Hyung | - |
dc.contributor.author | Hahm, Soo-Hyun | - |
dc.contributor.author | Park, Min Ju | - |
dc.contributor.author | Lee, You Ri | - |
dc.contributor.author | Il Ko, Sung | - |
dc.contributor.author | Kang, Lin-Woo | - |
dc.contributor.author | Kim, Tae-Sung | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Han, Ye Sun | - |
dc.date.accessioned | 2021-09-07T09:08:20Z | - |
dc.date.available | 2021-09-07T09:08:20Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-08-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111754 | - |
dc.description.abstract | Ribosomal protein S3 (rpS3) is a multifunctional protein involved in translation, DNA repair, and apoptosis. The relationship between rpS3 and cyclin-dependent kinases (Cdks) involved in cell cycle regulation is not yet known. Here, we show that rpS3 is phosphorylated by Cdk1 in G2/M phase. Co-immunoprecipitation and GST pull-down assays revealed that Cdk1 interacted with rpS3. An in vitro kinase assay showed that Cdk1 phosphorylated rpS3 protein. Phosphorylation of rpS3 increased in nocodazole-arrested mitotic cells; however, treatment with Cdk1 inhibitor or Cdk1 siRNA significantly attenuated this phosphorylation event The phosphorylation of a mutant form of rpS3, T221A, was significantly reduced compared with wild-type rpS3. Decreased phosphorylation and nuclear accumulation of T221A was much more pronounced in G2/M phase. These results suggest that the phosphorylation of rpS3 by Cdk1 occurs at Thr221 during G2/M phase and, moreover, that this event is important for nuclear accumulation of rpS3. [BMB reports 2011; 44(8): 529-534] | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | DNA-REPAIR | - |
dc.subject | KINASE | - |
dc.subject | ASSOCIATION | - |
dc.subject | INHIBITION | - |
dc.subject | APOPTOSIS | - |
dc.subject | SUBSTRATE | - |
dc.subject | STRESS | - |
dc.subject | SITES | - |
dc.subject | DELTA | - |
dc.subject | CDK1 | - |
dc.title | Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.8.529 | - |
dc.identifier.scopusid | 2-s2.0-80052888731 | - |
dc.identifier.wosid | 000294514000006 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.44, no.8, pp.529 - 534 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 529 | - |
dc.citation.endPage | 534 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001578416 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | SITES | - |
dc.subject.keywordPlus | DELTA | - |
dc.subject.keywordPlus | CDK1 | - |
dc.subject.keywordAuthor | Cdk1/cdc2 | - |
dc.subject.keywordAuthor | Cell cycle | - |
dc.subject.keywordAuthor | Phosphorylation | - |
dc.subject.keywordAuthor | RpS3 | - |
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