Inhibitory Effect of 2-Arylbenzofurans from the Mori Cortex Radicis (Moraceae) on Oxygen Glucose Deprivation (OGD)-induced Cell Death of SH-SY5Y Cells
- Authors
- Lee, Hak Ju; Lyu, Da Hyun; Koo, Uk; Lee, Sung-Jin; Hong, Seong Su; Kim, Kemok; Kim, Kyeong Ho; Lee, Dongho; Mar, Woongchon
- Issue Date
- 8월-2011
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Mori Cortex Radicis; Moraceae; 2-Arylbenzofurans; Oxygen-glucose deprivation; MTT; ROS
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.34, no.8, pp.1373 - 1380
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 34
- Number
- 8
- Start Page
- 1373
- End Page
- 1380
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111878
- DOI
- 10.1007/s12272-011-0818-4
- ISSN
- 0253-6269
- Abstract
- Three known 2-arylbenzofurans, moracin P (1), moracin 0 (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC50 values of 10.4, 12.6, and 15.9 mu M, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC50 values of 1.9, 0.3 and 12.1 mu M, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dose-dependent manner. Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.
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