Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty
DC Field | Value | Language |
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dc.contributor.author | Rhie, Young Jun | - |
dc.contributor.author | Lee, Kee Hyoung | - |
dc.contributor.author | Eun, So Hee | - |
dc.contributor.author | Choi, Byung Min | - |
dc.contributor.author | Chae, Hyun Wook | - |
dc.contributor.author | Kwon, Ah Reum | - |
dc.contributor.author | Lee, Woo Jung | - |
dc.contributor.author | Kim, Jung Hyun | - |
dc.contributor.author | Kim, Ho-Seong | - |
dc.date.accessioned | 2021-09-07T11:09:56Z | - |
dc.date.available | 2021-09-07T11:09:56Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112137 | - |
dc.description.abstract | Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 +/- 1.78 vs 2.15 +/- 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | METASTASIS-SUPPRESSOR GENE | - |
dc.subject | PROTEIN-COUPLED RECEPTOR | - |
dc.subject | PREMATURE THELARCHE | - |
dc.subject | KISS-1 PEPTIDE | - |
dc.subject | HYPOGONADOTROPIC HYPOGONADISM | - |
dc.subject | EARLY DIFFERENTIATION | - |
dc.subject | HORMONE NEURONS | - |
dc.subject | NATURAL LIGAND | - |
dc.subject | GPR54 | - |
dc.subject | G-PROTEIN-COUPLED-RECEPTOR-54 | - |
dc.title | Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhie, Young Jun | - |
dc.contributor.affiliatedAuthor | Lee, Kee Hyoung | - |
dc.contributor.affiliatedAuthor | Eun, So Hee | - |
dc.contributor.affiliatedAuthor | Choi, Byung Min | - |
dc.identifier.doi | 10.3346/jkms.2011.26.7.927 | - |
dc.identifier.scopusid | 2-s2.0-79960128379 | - |
dc.identifier.wosid | 000292521600013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.7, pp.927 - 931 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 927 | - |
dc.citation.endPage | 931 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001567184 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | METASTASIS-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | PREMATURE THELARCHE | - |
dc.subject.keywordPlus | KISS-1 PEPTIDE | - |
dc.subject.keywordPlus | HYPOGONADOTROPIC HYPOGONADISM | - |
dc.subject.keywordPlus | EARLY DIFFERENTIATION | - |
dc.subject.keywordPlus | HORMONE NEURONS | - |
dc.subject.keywordPlus | NATURAL LIGAND | - |
dc.subject.keywordPlus | GPR54 | - |
dc.subject.keywordPlus | G-PROTEIN-COUPLED-RECEPTOR-54 | - |
dc.subject.keywordAuthor | Kisspeptin | - |
dc.subject.keywordAuthor | KISS1 Gene | - |
dc.subject.keywordAuthor | G-protein Coupled Receptor-54 | - |
dc.subject.keywordAuthor | Central Precocious Puberty | - |
dc.subject.keywordAuthor | Gonadotropin-Releasing Hormone | - |
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