Exercise training improves basal blood glucose metabolism with no changes of cytosolic inhibitor kappa B kinase or c-Jun N-terminal kinase activation in skeletal muscle of Otsuka Long-Evans Tokushima fatty rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Hojun | - |
dc.contributor.author | Chang, Hyukki | - |
dc.contributor.author | Park, Jae-Young | - |
dc.contributor.author | Kim, Si-Young | - |
dc.contributor.author | Choi, Kyung-Mook | - |
dc.contributor.author | Song, Wook | - |
dc.date.accessioned | 2021-09-07T11:17:08Z | - |
dc.date.available | 2021-09-07T11:17:08Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0958-0670 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112177 | - |
dc.description.abstract | Redox-sensitive stress kinases and heat shock protein 72 (Hsp72) have been considered to be associated with the development of type 2 diabetes in skeletal muscle. However, the effect of exercise training on skeletal muscle of type 2 diabetic models is largely unknown. The purpose of this study was to investigate the effect of 12 weeks of exercise training on gastrocnemius of type 2 diabetic rats, by examining the activation of c-Jun N-terminal kinase (JNK), the nuclear factor kappa B (NF-kappa B) pathway and Hsp72. Total hydroperoxide and 4-hydroxynoneal, as oxidative stress markers, were also examined. Otsuka Long-Evans Tokushima fatty (OLEFT) rats were randomly divided into an exercise training group (Ex-OLETF, n = 8) and a sedentary group (Sed-OLETF, n = 8), while Long-Evans Tokushima Otsuka (LETO) rats were used as a control group (Con-LETO, n = 5). The Ex-OLETF rats were trained on a treadmill five times a week for 12 weeks. The levels of hydroperoxide and 4-hydroxynoneal in both Ex-OLETF and Sed-OLETF were significantly higher compared with Con-LETO, but there was no difference between Ex-OLETF and Sed-OLETF. Levels of inhibitor kappa B kinase, JNK activation and p65 nuclear translocation followed a similar pattern to that observed in oxidative stress markers. The level of Hsp72 in Ex-OLETF was increased by exercise training, but it did not reach the level observed in Con-LETO. The NF-kappa B DNA binding activity in Sed-OLETF was significantly higher compared with Con-LETO. Although it was not statistically significant, exercise training in Ex-OLETF showed a trend to reduce the activation of NF-kappa B DNA binding activity compared with Sed-OLETF (P = 0.104). Our findings indicate that exercise training improves basal glucose metabolism without a change in stress kinases, and that nuclear regulation of NF-kappa B activity in diabetic muscle could be regulated independently of the cytosolic pathway. Our study also suggests a possibility that exercise-induced Hsp72 serves as a protective mechanism in skeletal muscle of OLETF rats. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | INDUCED INSULIN-RESISTANCE | - |
dc.subject | INDUCED OXIDATIVE STRESS | - |
dc.subject | CONTRACTILE ACTIVITY | - |
dc.subject | NH2-TERMINAL KINASE | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | ADAPTIVE RESPONSES | - |
dc.subject | IKK-BETA | - |
dc.subject | OBESITY | - |
dc.subject | ALPHA | - |
dc.subject | INFLAMMATION | - |
dc.title | Exercise training improves basal blood glucose metabolism with no changes of cytosolic inhibitor kappa B kinase or c-Jun N-terminal kinase activation in skeletal muscle of Otsuka Long-Evans Tokushima fatty rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Kyung-Mook | - |
dc.identifier.doi | 10.1113/expphysiol.2011.057737 | - |
dc.identifier.scopusid | 2-s2.0-79959378466 | - |
dc.identifier.wosid | 000292105200008 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL PHYSIOLOGY, v.96, no.7, pp.689 - 698 | - |
dc.relation.isPartOf | EXPERIMENTAL PHYSIOLOGY | - |
dc.citation.title | EXPERIMENTAL PHYSIOLOGY | - |
dc.citation.volume | 96 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 689 | - |
dc.citation.endPage | 698 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CONTRACTILE ACTIVITY | - |
dc.subject.keywordPlus | NH2-TERMINAL KINASE | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | ADAPTIVE RESPONSES | - |
dc.subject.keywordPlus | IKK-BETA | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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