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pH-Triggered Drug-Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI

Authors
Lim, Eun-KyungHuh, Yong-MinYang, JaemoonLee, KwangyeolSuh, Jin-SuckHaam, Seungjoo
Issue Date
3-6월-2011
Publisher
WILEY-V C H VERLAG GMBH
Keywords
drug delivery; magnetic resonance imaging; nanoparticles; theragnostics
Citation
ADVANCED MATERIALS, v.23, no.21, pp.2436 - +
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED MATERIALS
Volume
23
Number
21
Start Page
2436
End Page
+
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/112249
DOI
10.1002/adma.201100351
ISSN
0935-9648
Abstract
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
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