HIF-1 alpha inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xia, Yan | - |
dc.contributor.author | Jin, Yinglan | - |
dc.contributor.author | Kaur, Navneet | - |
dc.contributor.author | Choi, Yongseok | - |
dc.contributor.author | Lee, Kyeong | - |
dc.date.accessioned | 2021-09-07T11:45:22Z | - |
dc.date.available | 2021-09-07T11:45:22Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112274 | - |
dc.description.abstract | The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1 alpha protein accumulation and target gene expression under hypoxia. (C) 2011 Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | INDUCIBLE FACTOR-I | - |
dc.subject | HIF-1 | - |
dc.subject | PAS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | FAMILY | - |
dc.subject | TARGET | - |
dc.subject | MODEL | - |
dc.title | HIF-1 alpha inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1016/j.ejmech.2011.03.022 | - |
dc.identifier.scopusid | 2-s2.0-79955579927 | - |
dc.identifier.wosid | 000291118600046 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.6, pp.2386 - 2396 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2386 | - |
dc.citation.endPage | 2396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | INDUCIBLE FACTOR-I | - |
dc.subject.keywordPlus | HIF-1 | - |
dc.subject.keywordPlus | PAS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Moracin | - |
dc.subject.keywordAuthor | Arylbenzofuran | - |
dc.subject.keywordAuthor | HIF-1 alpha | - |
dc.subject.keywordAuthor | Structure-activity relationships | - |
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