Urine Neural Thread Protein Measurements in Alzheimer Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | Park, Kun-Woo | - |
dc.contributor.author | Han, Seol-Heui | - |
dc.contributor.author | Kim, SangYun | - |
dc.date.accessioned | 2021-09-07T12:01:30Z | - |
dc.date.available | 2021-09-07T12:01:30Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1525-8610 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112335 | - |
dc.description.abstract | Objectives: Neural thread protein (NTP), a membrane-associated phosphoprotein, was selectively elevated in the urine of patients with Alzheimer disease (AD). To demonstrate the potential utility of urine NTP assays for the diagnosis of AD, we performed this study. Design: A prospective blinded multicentered study. Participants: Individuals diagnosed as having probable AD (n = 49), Parkinson's disease (PD) (n = 20), and healthy controls (n = 22) were enrolled consecutively in 4 neurology centers. Measurements: A first morning urine sample was obtained from each subject. Urine NTP measurement using competitive ELISA was tested at the central laboratory and compared with AD and PD patients and healthy controls (HC). The testing laboratory was blinded to clinical information. Results: The mean assay value in AD (n = 49, 26.8 +/- 9.4 mu g/mL) was significantly higher than in HC (n = 22, 18.1 +/- 6.7 mu g/mL) (P <= .001) and than in PD (n = 20, 21.0 +/- 8.5, mu g/mL) (P <= .05). Levels of 21.6 mu g/mL or higher were found in 81.6% of all AD cases, in 30.0% of PD cases, and in 13.6% of HC. Urine NTP assay measurements of AD with a Clinical Dementia Rate (CDR) of 0.5 (n = 10, 24.2 +/- 5.9 mu g/mL, P = .063) or of 1.0 (n = 24, 30.1 +/- 10.9 mu g/mL, P = .000) were significantly higher than in HC. However, the AD patients with CDR of 2.0 (n = 9, 23.1 +/- 7.3 mu g/mL, P = .136) were not significant. Conclusion: Urine NTP could be used as a safe and promising biochemical marker of early AD. (J Am Med Dir Assoc 2011; 12: 372-376) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | MILD COGNITIVE IMPAIRMENT | - |
dc.subject | CEREBROSPINAL-FLUID | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CSF BIOMARKERS | - |
dc.subject | AD7C-NTP | - |
dc.subject | MARKER | - |
dc.subject | TAU | - |
dc.title | Urine Neural Thread Protein Measurements in Alzheimer Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kun-Woo | - |
dc.identifier.doi | 10.1016/j.jamda.2010.03.004 | - |
dc.identifier.scopusid | 2-s2.0-79956276498 | - |
dc.identifier.wosid | 000292061300009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, v.12, no.5, pp.372 - 376 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION | - |
dc.citation.title | JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 372 | - |
dc.citation.endPage | 376 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CSF BIOMARKERS | - |
dc.subject.keywordPlus | AD7C-NTP | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | TAU | - |
dc.subject.keywordAuthor | Alzheimer disease | - |
dc.subject.keywordAuthor | biological marker | - |
dc.subject.keywordAuthor | neural thread protein | - |
dc.subject.keywordAuthor | Parkinson disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.