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Biomarker discovery and proteomic evaluation of cadmium toxicity on a collembolan species, Paronychiurus kimi (Lee)

Authors
Son, JinoLee, Sung-EunPark, Byeoung-SooJung, JinhoPark, Hyung SoonBang, Joo YoungKang, Gum-YongCho, Kijong
Issue Date
6월-2011
Publisher
WILEY
Keywords
1-D PAGE; 2-D PAGE; Animal proteomics; Biomarkers; Cadmium; LC-MS/MS
Citation
PROTEOMICS, v.11, no.11, pp.2294 - 2307
Indexed
SCIE
SCOPUS
Journal Title
PROTEOMICS
Volume
11
Number
11
Start Page
2294
End Page
2307
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/112356
DOI
10.1002/pmic.200900690
ISSN
1615-9853
Abstract
The goal of this study was to identify promising new biomarkers of cadmium by identifying differentially expressed proteins in Paronychiurus kimi after exposure to cadmium. Through proteomic analysis of P. kimi using 1-D PAGE and nano-LC-MS/MS, 36 downregulated proteins and 40 upregulated proteins were found. Some of the downregulated and upregulated proteins were verified by LC-MS/MS analysis after 2-D PAGE. Downregulated proteins in response to cadmium exposure were involved in glycolysis and energy metabolism, chaperones, transcription, reproduction, and neuron growth. In contrast, proteins involved in glycolysis and energy production, neurogenesis, defense systems response to bacteria, and protein biosynthesis were upregulated in cadmium-treated collembolans. Cubulin may be a potential biomarker for the detection of cadmium in P. kimi since this biomarker was able to low levels (3.5 mg/kg) of cadmium. The 14-3-3 zeta was also found to be a potential biomarker for the detection of medium levels (14 mg/kg) of cadmium. Collembolans may be an alternative tool to humans because many collembolans proteins show a high homology to human proteins.
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생명과학대학 (환경생태공학부)
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