Stabilization of the survival motor neuron protein by ASK1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jeong Eun | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.date.accessioned | 2021-09-07T12:33:30Z | - |
dc.date.available | 2021-09-07T12:33:30Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-05-06 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112464 | - |
dc.description.abstract | The survival motor neuron (SMN) is a spliceosomal snRNP-interacting protein that was initially identified as a defective molecule in spinal muscular atrophy (SMA). The disease severity of SMA is determined by SMN protein level. Here, we show that apoptosis signal-regulating kinase 1 (ASK1) stabilizes SMN protein by inhibiting SMN poly-ubiquitination, and that the kinase activity of ASK1 is less important than its ability to bind to SMN. Furthermore, depletion of ASK1 by RNA interference revealed that ASK1 modulates neurite outgrowth by regulating SMN protein level in NSC34 motor neuron-like cells. Collectively, our results suggest that ASK1 acts as a novel binding partner of SMN and controls the steady-state level of SMN through complex formation with SMN in neurite outgrowth. Structured summary of protein interactions: ASK1 physically interacts with SMN1 by anti tag coimmunoprecipitation (View interaction) SMN1 physically interacts with ASK1 by anti tag coimmunoprecipitation (View interaction) ASK1 physically interacts with SMN1 by anti bait coimmunoprecipitation (View interaction) ASK1 physically interacts with SMNdelta7 by two hybrid (View interaction) (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | SIGNAL-REGULATING KINASE | - |
dc.subject | SPINAL MUSCULAR-ATROPHY | - |
dc.subject | TARGETING ASK1 | - |
dc.subject | PATHWAY | - |
dc.subject | APOPTOSIS | - |
dc.subject | ROLES | - |
dc.subject | PLAYS | - |
dc.subject | CELLS | - |
dc.subject | SMN2 | - |
dc.title | Stabilization of the survival motor neuron protein by ASK1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.identifier.doi | 10.1016/j.febslet.2011.04.011 | - |
dc.identifier.scopusid | 2-s2.0-79955602279 | - |
dc.identifier.wosid | 000290248300006 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.9, pp.1287 - 1292 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1287 | - |
dc.citation.endPage | 1292 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | SIGNAL-REGULATING KINASE | - |
dc.subject.keywordPlus | SPINAL MUSCULAR-ATROPHY | - |
dc.subject.keywordPlus | TARGETING ASK1 | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | PLAYS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SMN2 | - |
dc.subject.keywordAuthor | Apoptosis signal-regulating kinase 1 (ASK1) | - |
dc.subject.keywordAuthor | Spinal muscular atrophy (SMA) | - |
dc.subject.keywordAuthor | Survival motor neuron (SMN) | - |
dc.subject.keywordAuthor | Ubiquitination | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.