Clinical parameters including serum pepsinogen level and management strategy in patients with premalignant gastric dysplasia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Young Woon | - |
dc.contributor.author | Hwangbo, Young | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Jo, Sook Jung | - |
dc.contributor.author | Cho, Jun Hyung | - |
dc.contributor.author | Shim, Jaejun | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Hyo Jong | - |
dc.contributor.author | Kim, Byung Ho | - |
dc.date.accessioned | 2021-09-07T12:43:25Z | - |
dc.date.available | 2021-09-07T12:43:25Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0954-691X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112519 | - |
dc.description.abstract | Objective Surgical or endoscopic resection is recommended for the management of gastric high-grade dysplasia (HGD). However, there are no proper guidelines for the management of gastric low-grade dysplasia (LGD). We evaluated clinical parameters, histological results, and endoscopic follow-up to find a management strategy of LGD. Methods A total of 590 patients with LGD, HGD, functional dyspepsia (FD), and early or advanced gastric cancer (EGC or AGC, respectively) were consecutively enrolled. We examined the association of clinical parameters including low serum pepsinogen (PG) I/II ratio of 3.0 or less with the disease phenotypes. Histological results between initial forceps biopsy and final endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) specimens were compared. Complications and recurrence were evaluated after EMR or ESD. Results The PG I/II ratio in FD was 4.2 +/- 1.7 (mean +/- SD), but was significantly lower in LGD (2.8 +/- 1.6, P<0.0001). The PG I/II ratio was not any lower in the HGD, EGC, and AGC groups. In patients with FD having a PG I/II ratio of 3.0 or less, multiple logistic regression analysis showed smoking habits and high salt intake were independent risk factors for gastric dysplasia or gastric cancer. About 11% (n=8/70) of LGD lesions were upgraded to HGD (6/70) or EGC (2/70) after EMR or ESD. Neither serious complications nor recurrence at the primary site after EMR or ESD were found in LGD. Conclusion It is proposed that endoscopic resection followed by endoscopic surveillance might be a beneficial strategy for patients with LGD having a PG I/II ratio of 3.0 or less. Eur J Gastroenterol Hepatol 23: 405-410 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ENDOSCOPIC MUCOSAL RESECTION | - |
dc.subject | FOLLOW-UP | - |
dc.subject | CANCER | - |
dc.subject | CLASSIFICATION | - |
dc.subject | ATROPHY | - |
dc.subject | POPULATION | - |
dc.subject | CARCINOMA | - |
dc.subject | DIAGNOSIS | - |
dc.subject | HISTOLOGY | - |
dc.subject | POLYPS | - |
dc.title | Clinical parameters including serum pepsinogen level and management strategy in patients with premalignant gastric dysplasia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae Won | - |
dc.identifier.doi | 10.1097/MEG.0b013e328346105a | - |
dc.identifier.scopusid | 2-s2.0-79955061627 | - |
dc.identifier.wosid | 000289506800006 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, v.23, no.5, pp.405 - 410 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 405 | - |
dc.citation.endPage | 410 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ENDOSCOPIC MUCOSAL RESECTION | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | HISTOLOGY | - |
dc.subject.keywordPlus | POLYPS | - |
dc.subject.keywordAuthor | gastric dysplasia | - |
dc.subject.keywordAuthor | management strategy | - |
dc.subject.keywordAuthor | pepsinogen I/II ratio | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.