Efficacy of Para-Aortic Lymphadenectomy in Early-Stage Endometrioid Uterine Corpus Cancer
DC Field | Value | Language |
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dc.contributor.author | Tong, Seo-Yun | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.contributor.author | Kim, Jae Weon | - |
dc.contributor.author | Cho, Chi-Heum | - |
dc.contributor.author | Kim, Seok-Mo | - |
dc.contributor.author | Park, Sang-Yoon | - |
dc.contributor.author | Park, Chan-Yong | - |
dc.contributor.author | Kim, Ki-Tae | - |
dc.date.accessioned | 2021-09-07T12:45:00Z | - |
dc.date.available | 2021-09-07T12:45:00Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112528 | - |
dc.description.abstract | The objective of this study was to assess whether para-aortic lymphadenectomy has therapeutic efficacy for patients with early-stage endometrioid uterine cancer who underwent systematic pelvic lymphadenectomy. The authors retrospectively reviewed the medical records and pathological findings of 547 patients with histologically proven FIGO stage I-II endometrioid uterine cancer, based on comprehensive surgical staging, including pelvic with or without para-aortic lymphadenectomy. Among 547 patients, 330 patients had systematic pelvic lymphadenectomy only, and 217 had systematic pelvic with para-aortic lymphadenectomy. There were no significant differences in histopathological factors in the high-risk group, even though deep myometrial invasion (p = 0.02) and lymphvascular space invasion (p = 0.01) were more common in patients who underwent systematic pelvic with para-aortic lymphadenectomy in all study populations. Within a median follow-up of 31 (range, 5-120) months, there was no significant difference in overall survival between the pelvic lymphadenectomy only and pelvic with para-aortic lymphadenectomy groups in all populations (p = 0.77), even in high-risk patients (p = 0.82). Upon multivariate analysis, patients with lymphvascular space invasion had significantly worse overall survival (odds ratio (OR) = 7.38; 95% confidence interval (CI) = 1.86-29.23; p = 0.004). Although a prospective, randomized study needs to be performed for confirmation, our data suggest that the therapeutic benefit of para-aortic lymphadenectomy is uncertain in stage I and II endometrioid uterine corpus cancer, even in patients at high-risk for recurrence. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CARCINOMA | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | MANAGEMENT | - |
dc.subject | SURVIVAL | - |
dc.subject | TRIAL | - |
dc.subject | RADIOTHERAPY | - |
dc.title | Efficacy of Para-Aortic Lymphadenectomy in Early-Stage Endometrioid Uterine Corpus Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Kwan | - |
dc.identifier.doi | 10.1245/s10434-010-1472-7 | - |
dc.identifier.scopusid | 2-s2.0-79955800191 | - |
dc.identifier.wosid | 000289564600033 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, v.18, no.5, pp.1425 - 1430 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.title | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1425 | - |
dc.citation.endPage | 1430 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
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