Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women
- Authors
- Seol, Hyun-Joo; Kim, Jae-Won; Kim, Hai-Joong
- Issue Date
- 5월-2011
- Publisher
- WALTER DE GRUYTER GMBH
- Keywords
- Preeclampsia; pregnancy; retinol-binding protein-4
- Citation
- JOURNAL OF PERINATAL MEDICINE, v.39, no.3, pp.287 - 289
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PERINATAL MEDICINE
- Volume
- 39
- Number
- 3
- Start Page
- 287
- End Page
- 289
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112572
- DOI
- 10.1515/JPM.2011.016
- ISSN
- 0300-5577
- Abstract
- Aims: The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women. Methods: The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia. Results: Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 mu g/mL vs. 202.0 mu g/mL, P < 0.001; umbilical cord serum, median 147.9 mu g/mL vs. 193.0 mu g/mL, P < 0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum. Conclusion: Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.
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