Bcl-X-L prevents serum deprivation-induced oxidative stress mediated by Romo1
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Baek | - |
dc.contributor.author | Kim, Hyung Jung | - |
dc.contributor.author | Shin, Jungar | - |
dc.contributor.author | Kang, Sung Tae | - |
dc.contributor.author | Kang, Seongman | - |
dc.contributor.author | Yoo, Young Do | - |
dc.date.accessioned | 2021-09-07T13:00:31Z | - |
dc.date.available | 2021-09-07T13:00:31Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112590 | - |
dc.description.abstract | B-cell lymphoma-extra large (Bcl-X-L) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (Romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS). Therefore, we investigated whether Bcl-X-L expression could inhibit the serum deprivation-induced increase in ROS and cell death, which are mediated by Romo1. We found that Bcl-X-L, expression effectively blocked serum deprivation- and Romo1-triggered ROS generation. Bcl-X-L. also inhibited apoptotic cell death induced by both serum deprivation and oxidative stress. From these results, we suggest that increased Bcl-X-L expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | CELL-DEATH | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | ROS PRODUCTION | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | SURVIVAL | - |
dc.subject | WITHDRAWAL | - |
dc.subject | BCL-X(L) | - |
dc.subject | RELEASE | - |
dc.subject | PATHWAY | - |
dc.title | Bcl-X-L prevents serum deprivation-induced oxidative stress mediated by Romo1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seongman | - |
dc.contributor.affiliatedAuthor | Yoo, Young Do | - |
dc.identifier.doi | 10.3892/or.2011.1210 | - |
dc.identifier.scopusid | 2-s2.0-79953038617 | - |
dc.identifier.wosid | 000289817300018 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.25, no.5, pp.1337 - 1342 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1337 | - |
dc.citation.endPage | 1342 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | ROS PRODUCTION | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | WITHDRAWAL | - |
dc.subject.keywordPlus | BCL-X(L) | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | reactive oxygen species modulator 1 | - |
dc.subject.keywordAuthor | B-cell lymphoma-extra large | - |
dc.subject.keywordAuthor | serum deprivation | - |
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