Protective Effect of Chlorogenic Acid against A beta-Induced Neurotoxicity
DC Field | Value | Language |
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dc.contributor.author | Lee, Chan Woo | - |
dc.contributor.author | Won, Tae Joon | - |
dc.contributor.author | Kim, Hak Rim | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Hwang, Kwang Woo | - |
dc.contributor.author | Park, So-Young | - |
dc.date.accessioned | 2021-09-07T13:05:27Z | - |
dc.date.available | 2021-09-07T13:05:27Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-04-30 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112619 | - |
dc.description.abstract | Beta-amyloid (A beta) is considered as one of the major causes of Alzheimer's disease. This study examined the neuroprotective effects of chlorogenic acid, a naturally occurring polyphenol which is distributed widely in plants, fruits and vegetables, against An-induced toxicity. A beta decreased significantly the viability of PC12 cells. This was accompanied by an increase in the intracellular calcium levels and cleaved caspase-3. In addition, A beta induced an increase in Bax, and a decrease in Bcl-2 compared to the controls. However, a pre-treatment with chlorogenic acid rescued the PC12 cells from A beta by attenuating the elevated intracellular calcium levels and reducing the levels of the apoptosis related proteins, including caspase-3, Bcl-2 and Bax. These results suggest that the protective effects of chlorogenic acid are, at least in parts, by attenuating the intracellular calcium influx and reducing apoptosis induced by A beta. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.subject | PC12 CELLS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | APOPTOSIS | - |
dc.subject | INHIBITION | - |
dc.subject | EXTRACTS | - |
dc.subject | CURCUMIN | - |
dc.subject | PROTEIN | - |
dc.subject | COFFEE | - |
dc.title | Protective Effect of Chlorogenic Acid against A beta-Induced Neurotoxicity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.4062/biomolther.2011.19.2.181 | - |
dc.identifier.scopusid | 2-s2.0-79956101898 | - |
dc.identifier.wosid | 000290705900005 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.19, no.2, pp.181 - 186 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 186 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001547049 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | COFFEE | - |
dc.subject.keywordAuthor | Chlorogenic acid | - |
dc.subject.keywordAuthor | Beta-amyloid | - |
dc.subject.keywordAuthor | Calcium influx | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | PC12 cells | - |
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