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A Mitochondrial-Targeted Two-Photon Probe for Zinc Ion

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dc.contributor.authorMasanta, Goutam-
dc.contributor.authorLim, Chang Su-
dc.contributor.authorKim, Hyung Joong-
dc.contributor.authorHan, Ji Hee-
dc.contributor.authorKim, Hwan Myung-
dc.contributor.authorCho, Bong Rae-
dc.date.accessioned2021-09-07T13:16:16Z-
dc.date.available2021-09-07T13:16:16Z-
dc.date.created2021-06-14-
dc.date.issued2011-04-20-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/112643-
dc.description.abstractWe report a two-photon probe (SZn-Mito) for mitochondrial zinc ions ([Zn2+](m)). This probe shows a 7-fold enhancement of two-photon-excited fluorescence in response to Zn2+ with a dissociation constant (K-d(TP)) of 3.1 +/- 0.1 nM and pH insensitivity in the biologically relevant range, allowing the detection of [Zn2+](m) in a rat hippocampal slice at a depth of 100-200 mu m without interference from other metal ions through the use of two-photon microscopy.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectFLUORESCENT-PROBES-
dc.subjectMETAL-IONS-
dc.subjectZN2+-
dc.subjectALZHEIMERS-
dc.subjectDISEASE-
dc.subjectSENSORS-
dc.subjectTISSUE-
dc.subjectCELLS-
dc.titleA Mitochondrial-Targeted Two-Photon Probe for Zinc Ion-
dc.typeArticle-
dc.contributor.affiliatedAuthorCho, Bong Rae-
dc.identifier.doi10.1021/ja200444t-
dc.identifier.scopusid2-s2.0-79954567773-
dc.identifier.wosid000290358200022-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.15, pp.5698 - 5700-
dc.relation.isPartOfJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.citation.titleJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.citation.volume133-
dc.citation.number15-
dc.citation.startPage5698-
dc.citation.endPage5700-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusFLUORESCENT-PROBES-
dc.subject.keywordPlusMETAL-IONS-
dc.subject.keywordPlusZN2+-
dc.subject.keywordPlusALZHEIMERS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusSENSORS-
dc.subject.keywordPlusTISSUE-
dc.subject.keywordPlusCELLS-
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