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Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

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dc.contributor.authorYoon, Hey Young-
dc.contributor.authorShim, So Hee-
dc.contributor.authorBaek, Luck Ju-
dc.contributor.authorHong, Jong-In-
dc.date.accessioned2021-09-07T13:18:34Z-
dc.date.available2021-09-07T13:18:34Z-
dc.date.created2021-06-14-
dc.date.issued2011-04-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/112655-
dc.description.abstractLeucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. (C) 2011 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectFLUORESCENCE DETECTION-
dc.subjectDCDHF FLUOROPHORES-
dc.subjectINHIBITORS-
dc.subjectASSAY-
dc.titleSmall-molecule probe using dual signals to monitor leucine aminopeptidase activity-
dc.typeArticle-
dc.contributor.affiliatedAuthorBaek, Luck Ju-
dc.identifier.doi10.1016/j.bmcl.2011.02.068-
dc.identifier.scopusid2-s2.0-79953268294-
dc.identifier.wosid000289074700048-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.8, pp.2403 - 2405-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume21-
dc.citation.number8-
dc.citation.startPage2403-
dc.citation.endPage2405-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusFLUORESCENCE DETECTION-
dc.subject.keywordPlusDCDHF FLUOROPHORES-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusASSAY-
dc.subject.keywordAuthorLeucine aminopeptidases-
dc.subject.keywordAuthorProbe-
dc.subject.keywordAuthorDual signals-
dc.subject.keywordAuthor2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit-
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