Long-term randomized controlled trial of a novel nanopowder hemostatic agent (TC-325) for control of severe arterial upper gastrointestinal bleeding in a porcine model
DC Field | Value | Language |
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dc.contributor.author | Giday, S. A. | - |
dc.contributor.author | Kim, Y. | - |
dc.contributor.author | Krishnamurty, D. M. | - |
dc.contributor.author | Ducharme, R. | - |
dc.contributor.author | Liang, D. B. | - |
dc.contributor.author | Shin, E. J. | - |
dc.contributor.author | Dray, X. | - |
dc.contributor.author | Hutcheon, D. | - |
dc.contributor.author | Moskowitz, K. | - |
dc.contributor.author | Donatelli, G. | - |
dc.contributor.author | Rueben, D. | - |
dc.contributor.author | Canto, M. I. | - |
dc.contributor.author | Okolo, P. I. | - |
dc.contributor.author | Kalloo, A. N. | - |
dc.date.accessioned | 2021-09-07T13:30:28Z | - |
dc.date.available | 2021-09-07T13:30:28Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0013-726X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112697 | - |
dc.description.abstract | Background and study aim: Endoscopic therapy of brisk upper gastrointestinal bleeding remains challenging. A proprietary nanopowder (TC-325) has been proven to be effective in high pressure bleeding from external wounds. The efficacy and safety of TC-325 were assessed in a survival gastrointestinal bleeding animal model. Method: 10 animals were randomized to treatment or sham. All animals received intravenous antibiotics, H2-blockers and heparin (activated clotting time 2 x normal). In a sterile laparotomy the gastroepiploic vessels were dissected, inserted through a 1-cm gastrotomy, and freely exposed in the gastric lumen, and the exposed vessel lacerated by needle knife. The treatment group received TC-325 by a modified delivery catheter while the sham group received no endoscopic treatment. Time to hemostasis, and mortality at 60 minutes, 24 hours, 48 hours, and 7 days were noted. Necropsy was performed in all animals. Results: Spurting arterial bleeding was achieved in all animals. No control animal showed hemostasis within the first hour compared with 100% (5/5) in the treatment arm (mean 13.8 minutes, P < 0.0079). Durable hemostasis was achieved with no evidence of rebleeding after 1 and 24 hours in 80% (4/5) of the treated animals compared with none in the control group (P < 0.0098). None of the control animals survived more than 6 hours. Necropsy at 1 week in treated animals revealed healed gastrotomy without foreign body granuloma or embolization to the lung or brain. Conclusion: TC-325 is safe and highly effective in achieving hemostasis in an anticoagulated severe arterial gastrointestinal bleeding animal model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | SWINE MODEL | - |
dc.subject | INJECTION | - |
dc.subject | HEMORRHAGE | - |
dc.subject | THERAPY | - |
dc.title | Long-term randomized controlled trial of a novel nanopowder hemostatic agent (TC-325) for control of severe arterial upper gastrointestinal bleeding in a porcine model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Y. | - |
dc.identifier.doi | 10.1055/s-0030-1256125 | - |
dc.identifier.scopusid | 2-s2.0-79953651939 | - |
dc.identifier.wosid | 000289056300003 | - |
dc.identifier.bibliographicCitation | ENDOSCOPY, v.43, no.4, pp.296 - 299 | - |
dc.relation.isPartOf | ENDOSCOPY | - |
dc.citation.title | ENDOSCOPY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 299 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SWINE MODEL | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | HEMORRHAGE | - |
dc.subject.keywordPlus | THERAPY | - |
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