Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach
DC Field | Value | Language |
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dc.contributor.author | Kim, Oh Yoen | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.contributor.author | Moon, Jiyoung | - |
dc.contributor.author | Chung, Ji Hyung | - |
dc.date.accessioned | 2021-09-07T13:37:19Z | - |
dc.date.available | 2021-09-07T13:37:19Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112735 | - |
dc.description.abstract | Objectives: This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques. Design and methods: Comparison of protein expression in plasma between non-obese (n=109, body mass index, BMI < 25 kg/m(2)) and obese (n=32, BMI >= 25 kg/m(2)) groups was carried out using two-dimensional gel electrophoresis (2-DE) analysis. ELISA was also performed for validation. Results: Among six differentially expressed protein spots, ceruloplasmin (Cp) and fibrinogen were over-expressed in obese group. Plasma Cp levels were significantly higher in obese group than non-obese group (34.0 +/- 8.6 vs. 41.3 +/- 12.7 mg/dL, p < 0.001) and positively correlated with age (r=0.253, p < 0.005), BMI (r=0.265, p < 0.001) and hsCRP (r=0.385, p < 0.001). In stepwise multiple linear regression analysis, plasma Cp along with hsCRP were found predictors for obesity (adjusted beta-coefficient=0.266, p < 0.01). Conclusion: Elevated plasma Cp levels were significantly associated with obesity, which may be suggested to be a marker of obesity. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INFLAMMATION | - |
dc.subject | MASS | - |
dc.subject | RISK | - |
dc.subject | FIBRINOGEN | - |
dc.subject | DISEASE | - |
dc.title | Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.01.014 | - |
dc.identifier.scopusid | 2-s2.0-79952765244 | - |
dc.identifier.wosid | 000288845000001 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, v.44, no.5-6, pp.351 - 356 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.citation.title | CLINICAL BIOCHEMISTRY | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 356 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | FIBRINOGEN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Two-dimensional gel electrophoresis | - |
dc.subject.keywordAuthor | Ceruloplasmin | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Proteomics | - |
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