Cytotoxic and Antineoplastic Activity of Timosaponin A-III for Human Colon Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Kang, You-Jin | - |
dc.contributor.author | Chung, Hwa-Jin | - |
dc.contributor.author | Nam, Joo-Won | - |
dc.contributor.author | Park, Hyen Joo | - |
dc.contributor.author | Seo, Eun Kyoung | - |
dc.contributor.author | Kim, Yeong Shik | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.date.accessioned | 2021-09-07T13:42:28Z | - |
dc.date.available | 2021-09-07T13:42:28Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112766 | - |
dc.description.abstract | The potential antitumor activity of timosaponin A-III (1), a steroidal saponin from the rhizomes of Anemarrhena asphodeloides, was investigated in;human colorectal cancer HCT-15 cells both in cell culture and in an in vivo murine xenograft model. Compound 1 inhibited the proliferation of cancer cells with cell-cycle arrest and induction of apoptosis. Cell-cycle, arrest in the GO/G1. and G2/M phase by 1 was correlated with the down-regulation of cyclin A, cyclin B1, cyclin-dependent kinase 2 (CDK2), CDK4, proliferating cell nuclear antigen, and c-Myc. The increase of the sub-G1 peak by 1 was also closely related to the induction of apoptosis, which was evidenced by the induction of DNA fragmentation, activation of caspases, induction of cleaved poly-(ADP ribose), polymerase, and suppression of Bcl-xL and Bcl-2 expression. In an in vivo xenograft model, treatment with 1 (2 or 5 mg/kg body weight, three times/week, ip administration) for four Week's significantly. suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity. Cell-cycle,arrest and induction of apoptosis might be plausible mechanisms of actions for the observed antineoplastic activity of. 1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ANEMARRHENA-ASPHODELOIDES | - |
dc.subject | STEROIDAL SAPONINS | - |
dc.subject | ANTITUMOR-ACTIVITY | - |
dc.subject | GROWTH-INHIBITION | - |
dc.subject | APOPTOSIS | - |
dc.subject | CYCLE | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PROTEIN | - |
dc.title | Cytotoxic and Antineoplastic Activity of Timosaponin A-III for Human Colon Cancer Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1021/np1007735 | - |
dc.identifier.scopusid | 2-s2.0-79955412969 | - |
dc.identifier.wosid | 000289742300025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.74, no.4, pp.701 - 706 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 74 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 706 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANEMARRHENA-ASPHODELOIDES | - |
dc.subject.keywordPlus | STEROIDAL SAPONINS | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CYCLE | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROTEIN | - |
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