Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy
- Authors
- Kim, Sung Hoon; Choi, Sae Byeol; Lee, Jae Gil; Kim, Seung Up; Park, Mi-Suk; Kim, Do Young; Choi, Jin Sub; Kim, Kyung Sik
- Issue Date
- 4월-2011
- Publisher
- SPRINGER
- Keywords
- HBeAg; Tumor size; Hepatocellular carcinoma; 10-Year survival
- Citation
- JOURNAL OF GASTROINTESTINAL SURGERY, v.15, no.4, pp.598 - 607
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROINTESTINAL SURGERY
- Volume
- 15
- Number
- 4
- Start Page
- 598
- End Page
- 607
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112788
- DOI
- 10.1007/s11605-011-1452-7
- ISSN
- 1091-255X
- Abstract
- There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24.1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
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