Epidemiology and Clinical Long-term Outcome of Childhood Aplastic Anemia in Korea for 15 Years: Retrospective Study of the Korean Society of Pediatric Hematology Oncology (KSPHO)
DC Field | Value | Language |
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dc.contributor.author | Jeong, Dae Chul | - |
dc.contributor.author | Chung, Nack Gyun | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.contributor.author | Kook, Hoon | - |
dc.contributor.author | Kim, Soon Ki | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Kim, Heung Sik | - |
dc.contributor.author | Kim, Hwang Min | - |
dc.contributor.author | Park, Kyung Duk | - |
dc.contributor.author | Park, Sang Kyu | - |
dc.contributor.author | Park, Jae Sun | - |
dc.contributor.author | Park, Jun Eun | - |
dc.contributor.author | Park, Hyeon Jin | - |
dc.contributor.author | Park, Young Shil | - |
dc.contributor.author | Seo, Jong Jin | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Ryu, Kun Hee | - |
dc.contributor.author | Ryu, Kyung Ha | - |
dc.contributor.author | Yoo, Eun Sun | - |
dc.contributor.author | Lyu, Chuhl Joo | - |
dc.contributor.author | Lee, Kun Soo | - |
dc.contributor.author | Lee, Kwang Chul | - |
dc.contributor.author | Lee, Soon Yong | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Lim, Young Tak | - |
dc.contributor.author | Lim, Yeon Jung | - |
dc.contributor.author | Jung, Hye Lim | - |
dc.contributor.author | Cho, Bin | - |
dc.contributor.author | Choi, Yong Mook | - |
dc.contributor.author | Hah, Jeong Ok | - |
dc.contributor.author | Hwang, Tai Ju | - |
dc.contributor.author | Kim, Hack Ki | - |
dc.date.accessioned | 2021-09-07T13:46:58Z | - |
dc.date.available | 2021-09-07T13:46:58Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1077-4114 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112791 | - |
dc.description.abstract | Purpose: Aplastic anemia (AA) is a rare hematologic disease characterized by pancytopenia and hypocellular marrow. The Korean Society of Pediatric Hematology Oncology investigated retrospectively the incidence, survival, and transfusion independency according to treatment strategies in AA. Methods: All the questionnaires were sent to members for medical records. We collected and analyzed 702 available data. Results: The male and female ratio was 1.2, and the median age at diagnosis was 9.3 years. The annual incidence of Korean children with AA was 5.16 per million per year. Constitutional anemia was diagnosed in 44 children. In acquired AA, causes were identified in 39 children. Severe AA (SAA) at initial diagnosis was more common than nonsevere AA. The overall survival was 47.8% with supportive care, 68.1% with immunosuppressive therapy (IST), and 81.8% with hematopoietic stem cell transplantation. In IST, response rate was 65.7%, and relapse rate after response was 54.4% within a median of 23.0 months. The factors with overall survival were severity of disease in supportive care, severity and response in IST, donor type, graft failure, and posttransplant events in hematopoietic stem cell transplantation. Conclusions: Long-term outcome in AA was dependent on treatment strategies. These Korean results may help research and prospective international clinical trials for childhood AA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | BONE-MARROW-TRANSPLANTATION | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | CORD BLOOD TRANSPLANTATION | - |
dc.subject | IMMUNOSUPPRESSIVE THERAPY | - |
dc.subject | ANTITHYMOCYTE GLOBULIN | - |
dc.subject | ANTILYMPHOCYTE GLOBULIN | - |
dc.subject | FOLLOW-UP | - |
dc.subject | CYCLOSPORINE | - |
dc.subject | CHILDREN | - |
dc.subject | PREDNISOLONE | - |
dc.title | Epidemiology and Clinical Long-term Outcome of Childhood Aplastic Anemia in Korea for 15 Years: Retrospective Study of the Korean Society of Pediatric Hematology Oncology (KSPHO) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Chul | - |
dc.identifier.doi | 10.1097/MPH.0b013e31820826a8 | - |
dc.identifier.scopusid | 2-s2.0-79954425115 | - |
dc.identifier.wosid | 000288694700014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, v.33, no.3, pp.172 - 178 | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | - |
dc.citation.title | JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | CORD BLOOD TRANSPLANTATION | - |
dc.subject.keywordPlus | IMMUNOSUPPRESSIVE THERAPY | - |
dc.subject.keywordPlus | ANTITHYMOCYTE GLOBULIN | - |
dc.subject.keywordPlus | ANTILYMPHOCYTE GLOBULIN | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | CYCLOSPORINE | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | PREDNISOLONE | - |
dc.subject.keywordAuthor | aplastic anemia | - |
dc.subject.keywordAuthor | long-term outcome | - |
dc.subject.keywordAuthor | children | - |
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