Blocking Fas Ligand on Leukocytes Attenuates Kidney Ischemia-Reperfusion Injury
DC Field | Value | Language |
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dc.contributor.author | Ko, Gang Jee | - |
dc.contributor.author | Jang, Hye Ryoun | - |
dc.contributor.author | Huang, Yanfei | - |
dc.contributor.author | Womer, Karl L. | - |
dc.contributor.author | Liu, Manchang | - |
dc.contributor.author | Higbee, Elizabeth | - |
dc.contributor.author | Xiao, Zuoxiang | - |
dc.contributor.author | Yagita, Hideo | - |
dc.contributor.author | Racusen, Lorraine | - |
dc.contributor.author | Hamad, Abdel Rahim A. | - |
dc.contributor.author | Rabb, Hamid | - |
dc.date.accessioned | 2021-09-07T13:49:01Z | - |
dc.date.available | 2021-09-07T13:49:01Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.issn | 1533-3450 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112801 | - |
dc.description.abstract | Inflammation contributes to the pathogenesis of ischemic acute kidney injury (AKI), and T cells mediate the early phase of ischemia-reperfusion injury (IRI). The Fas/Fas ligand (FasL) pathway modulates the balance of T cell subsets in the peripheral circulation as well as multiple inflammatory responses, suggesting that FasL may mediate ischemic AKI. Here, we induced bilateral renal IRI in mice bearing a loss-of-function mutation of FasL (the gld mutation) and in wild-type mice. Compared with wild-type mice, serum creatinine was lower in gld mice (1.4 +/- 0.9 mg/dl versus 2.6 +/- 0.4) at 24 hours after IRI (P < 0.05). In addition, gld mice had fewer TNF-alpha-producing T lymphocytes in the kidneys and renal lymph nodes. Furthermore, pharmacologic blockade of FasL protected the kidneys of wild-type mice from IRI. Analysis of bone marrow chimeric mice suggested that the pathogenic effect of FasL involves leukocytes; reconstitution of wild-type mice with gld splenocytes attenuated IRI. In contrast, reconstitution of gld mice with wild-type splenocytes enhanced IRI. These data demonstrate that FasL, particularly on leukocytes, mediates ischemic AKI. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC NEPHROLOGY | - |
dc.title | Blocking Fas Ligand on Leukocytes Attenuates Kidney Ischemia-Reperfusion Injury | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1681/ASN.2010010121 | - |
dc.identifier.scopusid | 2-s2.0-79953308080 | - |
dc.identifier.wosid | 000289494600020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.22, no.4, pp 732 - 742 | - |
dc.citation.title | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 732 | - |
dc.citation.endPage | 742 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | FAS/FAS LIGAND | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CD95 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DEATH | - |
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