Crystal Structure of a Coiled-Coil Domain from Human ROCK I
DC Field | Value | Language |
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dc.contributor.author | Tu, Daqi | - |
dc.contributor.author | Li, Yiqun | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.contributor.author | Toms, Angela V. | - |
dc.contributor.author | Gould, Christopher J. | - |
dc.contributor.author | Ficarro, Scott B. | - |
dc.contributor.author | Marto, Jarrod A. | - |
dc.contributor.author | Goode, Bruce L. | - |
dc.contributor.author | Eck, Michael J. | - |
dc.date.accessioned | 2021-09-07T14:05:49Z | - |
dc.date.available | 2021-09-07T14:05:49Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03-21 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112831 | - |
dc.description.abstract | The small GTPase Rho and one of its targets, Rho-associated kinase (ROCK), participate in a variety of actin-based cellular processes including smooth muscle contraction, cell migration, and stress fiber formation. The ROCK protein consists of an N-terminal kinase domain, a central coiled-coil domain containing a Rho binding site, and a C-terminal pleckstrin homology domain. Here we present the crystal structure of a large section of the central coiled-coil domain of human ROCK I (amino acids 535-700). The structure forms a parallel alpha-helical coiled-coil dimer that is structurally similar to tropomyosin, an actin filament binding protein. There is an unusual discontinuity in the coiled-coil; three charged residues (E613, R617 and D620) are positioned at what is normally the hydrophobic core of coiled-coil packing. We speculate that this conserved irregularity could function as a hinge that allows ROCK to adopt its autoinhibited conformation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | RHO-ASSOCIATED KINASE | - |
dc.subject | MYOSIN LIGHT-CHAIN | - |
dc.subject | SMOOTH-MUSCLE CONTRACTION | - |
dc.subject | SERINE/THREONINE KINASE | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | STRESS FIBERS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | BINDING | - |
dc.subject | ACTIVATION | - |
dc.subject | CYTOKINESIS | - |
dc.title | Crystal Structure of a Coiled-Coil Domain from Human ROCK I | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.contributor.affiliatedAuthor | Eck, Michael J. | - |
dc.identifier.doi | 10.1371/journal.pone.0018080 | - |
dc.identifier.scopusid | 2-s2.0-79952836685 | - |
dc.identifier.wosid | 000288613300035 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.6, no.3 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 6 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RHO-ASSOCIATED KINASE | - |
dc.subject.keywordPlus | MYOSIN LIGHT-CHAIN | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE CONTRACTION | - |
dc.subject.keywordPlus | SERINE/THREONINE KINASE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | STRESS FIBERS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOKINESIS | - |
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