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14-3-3 eta inhibits chondrogenic differentiation of ATDC5 cell

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dc.contributor.authorYoon, Hee Eun-
dc.contributor.authorKim, Ki Soon-
dc.contributor.authorKim, Ick Young-
dc.date.accessioned2021-09-07T14:15:27Z-
dc.date.available2021-09-07T14:15:27Z-
dc.date.created2021-06-14-
dc.date.issued2011-03-04-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/112865-
dc.description.abstractIt was previously shown that 14-3-3 eta is overexpressed in the synovial fluid of patients with joint inflammation, which is often associated with growth failure. In this study, we investigated the role of 14-3-3 eta in chondrogenesis using ATDC5 cells. Upon treatment with TNF-alpha, cells overexpressed 14-3-3 eta with inhibition of chondrogenesis. Chondrogenesis was also inhibited by overexpression of 14-3-3 eta without TNF-a treatment, whereas silencing of 14-3-3 eta promoted chondrogenic differentiation. Further, G1 phase arrest was inhibited by overexpression of 14-3-3 eta. In summary, we suggest that 14-3-3 eta plays a regulatory role in chondrogenic differentiation. (C) 2011 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectTUMOR-NECROSIS-FACTOR-
dc.subjectGROWTH-PLATE-
dc.subjectCHONDROCYTE DIFFERENTIATION-
dc.subjectINDUCED ARTHRITIS-
dc.subjectIN-VITRO-
dc.subjectEXPRESSION-
dc.subject14-3-3-PROTEINS-
dc.subjectSOX9-
dc.subjectINTERLEUKIN-1-BETA-
dc.subjectPROTEINS-
dc.title14-3-3 eta inhibits chondrogenic differentiation of ATDC5 cell-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Ick Young-
dc.identifier.doi10.1016/j.bbrc.2011.01.107-
dc.identifier.scopusid2-s2.0-79952195352-
dc.identifier.wosid000288302100011-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.406, no.1, pp.59 - 63-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume406-
dc.citation.number1-
dc.citation.startPage59-
dc.citation.endPage63-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusTUMOR-NECROSIS-FACTOR-
dc.subject.keywordPlusGROWTH-PLATE-
dc.subject.keywordPlusCHONDROCYTE DIFFERENTIATION-
dc.subject.keywordPlusINDUCED ARTHRITIS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlus14-3-3-PROTEINS-
dc.subject.keywordPlusSOX9-
dc.subject.keywordPlusINTERLEUKIN-1-BETA-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordAuthorChondrogenesis-
dc.subject.keywordAuthor14-3-3 eta-
dc.subject.keywordAuthorJoint inflammation-
dc.subject.keywordAuthorATDC5 cells-
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