Effect of microencapsulated precipitants of Lactobacillus casei ATCC 393 on Helicobacter pylori eradication
- Authors
- Ko, J. A.; Lim, H. J.; Park, H. J.
- Issue Date
- 3월-2011
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Lactobacillus casei ATCC 393; Helicobacter pylori; Chitosan; Poly-gamma-glutamic; Microspheres
- Citation
- PROCESS BIOCHEMISTRY, v.46, no.3, pp.631 - 635
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCESS BIOCHEMISTRY
- Volume
- 46
- Number
- 3
- Start Page
- 631
- End Page
- 635
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112879
- DOI
- 10.1016/j.procbio.2010.10.012
- ISSN
- 1359-5113
- Abstract
- Precipitants of Lactobacillus casei ATCC 393-loaded chitosan microspheres were prepared by electrostatic interaction between chitosan (CS) and poly-gamma-glutamic acid (gamma-PGA). The loading efficiency was approximately 80%, and the zeta potential of the microspheres became more positively charged as the molar ratio of the chitosan amino group was increased. The particles were confirmed to have a spherical shape by optical microscopy. A release test using simulated gastric fluid (SGF) was also performed. The results show that the precipitants were gradually released from the CS-gamma-PGA microspheres at a rate of almost 80% after 60 min. Both the inhibition of Helicobacter pylori growth and the anti-adhesive activity of encapsulated precipitants were maintained after exposure to SGF. These results indicate that CS-gamma-PGA microspheres may provide a delivery system for the effective eradication of H. pylori. (C) 2010 Elsevier Ltd. All rights reserved.
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