Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
- Authors
- Lee, Hyo-Suk; Yoo, Byung Chul; Lee, Kwan Sik; Kim, Ju Hyun; Um, Soon-Ho; Ryu, Soo Hyung; Lee, Young-Suk; Kim, Young Soo; Yoo, Kwon; Han, Joon-Yeol; Hwang, Jae Seok; Kim, Tae-Hun; Yang, Jin-Mo; Lee, Heon-Ju; Chon, Chae Yoon; Cho, Mong; Han, Byung Hoon; Hwang, Seong Gyu; Byun, Kwan Soo; Chung, Young-Hwa; Cho, Se-Hyun; Koh, Kwang Cheol; Kim, Byung-Ik; Kim, Haak Cheoul; Paik, Seung Woon; Lee, Myung-Seok; Yoo, Hee-Won; Han, Cheol Ju
- Issue Date
- 3월-2011
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Hepatitis B virus; HBV DNA; ccc-DNA; HBeAg seroconversion; HBsAg loss
- Citation
- JOURNAL OF GASTROENTEROLOGY, v.46, no.3, pp.410 - 414
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY
- Volume
- 46
- Number
- 3
- Start Page
- 410
- End Page
- 414
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112892
- DOI
- 10.1007/s00535-010-0354-x
- ISSN
- 0944-1174
- Abstract
- This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA < 4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA < 4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B. Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA < 141,500 and < 4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (-0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment.
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