Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bang, Sunhoe | - |
dc.contributor.author | Hyun, Seogang | - |
dc.contributor.author | Hong, Sung-Tae | - |
dc.contributor.author | Kang, Jongkyun | - |
dc.contributor.author | Jeong, Kyunghwa | - |
dc.contributor.author | Park, Joong-Jean | - |
dc.contributor.author | Choe, Joonho | - |
dc.contributor.author | Chung, Jongkyeong | - |
dc.date.accessioned | 2021-09-07T14:27:36Z | - |
dc.date.available | 2021-09-07T14:27:36Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112906 | - |
dc.description.abstract | The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However, neuromodulators that control the TPB in MB remain unknown. To identify the functions of dopamine in TPB, we have conducted various genetic studies in Drosophila. Inhibition of dopamine biosynthesis by genetic mutations or treatment with chemical inhibitors caused flies to prefer temperatures colder than normal. We also found that dopaminergic neurons are involved in TPB regulation, as the targeted inactivation of dopaminergic neurons by expression of a potassium channel (Kir2.1) induced flies with the loss of cold avoidance. Consistently, the mutant flies for dopamine receptor gene (DopR) also showed a cold temperature preference, which was rescued by MB-specific expression of DopR. Based on these results, we concluded that dopamine in MB is a key component in the homeostatic temperature control of Drosophila. The current findings will provide important bases to understand the logic of thermosensation and temperature preference decision in Drosophila. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | MALE COURTSHIP BEHAVIOR | - |
dc.subject | SYNAPTIC TRANSMISSION | - |
dc.subject | TYROSINE-HYDROXYLASE | - |
dc.subject | ADULT DROSOPHILA | - |
dc.subject | CENTRAL COMPLEX | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | MEMORY TRACES | - |
dc.subject | BODY NEUROPIL | - |
dc.subject | TRP CHANNELS | - |
dc.subject | MELANOGASTER | - |
dc.title | Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Joong-Jean | - |
dc.identifier.doi | 10.1371/journal.pgen.1001346 | - |
dc.identifier.scopusid | 2-s2.0-79953764383 | - |
dc.identifier.wosid | 000288996600028 | - |
dc.identifier.bibliographicCitation | PLOS GENETICS, v.7, no.3 | - |
dc.relation.isPartOf | PLOS GENETICS | - |
dc.citation.title | PLOS GENETICS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | MALE COURTSHIP BEHAVIOR | - |
dc.subject.keywordPlus | SYNAPTIC TRANSMISSION | - |
dc.subject.keywordPlus | TYROSINE-HYDROXYLASE | - |
dc.subject.keywordPlus | ADULT DROSOPHILA | - |
dc.subject.keywordPlus | CENTRAL COMPLEX | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | MEMORY TRACES | - |
dc.subject.keywordPlus | BODY NEUROPIL | - |
dc.subject.keywordPlus | TRP CHANNELS | - |
dc.subject.keywordPlus | MELANOGASTER | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.