Upregulation of interleukin-1 beta production by 1,25-Dihydroxyvitamin D-3 in activated human macrophages
DC Field | Value | Language |
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dc.contributor.author | Lee, Bit-Na-Ra | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Jun, Jae-Bum | - |
dc.contributor.author | Yoo, Dae-Hyun | - |
dc.contributor.author | Woo, Jin-Hyun | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Yongjin | - |
dc.contributor.author | Lee, Ji Young | - |
dc.contributor.author | Sohn, Jeongwon | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.date.accessioned | 2021-09-07T14:39:51Z | - |
dc.date.available | 2021-09-07T14:39:51Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112974 | - |
dc.description.abstract | 1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)D-3) plays important roles in the immune system. In contrast to its well known function in the adaptive immune system, much less is known about the immunoregulatory effects of 1,25(OH)(2)D-3 in the innate immune system, especially on activated human macrophages. Here we found that 1,25(OH)(2)D-3 strongly stimulated the production of interleukin-1 beta (IL-1 beta) in PMA-differentiated U937 cells and human monocyte-derived macrophages treated with lipopolysaccharide (LPS) or PMA. In this study, Erk1/2 appeared to mediate 1,25(OH)(2)D-3-induced expression of IL-1 beta. Parallel to the increased production of IL-1 beta, 1,25(OH)(2)D-3 increased the expression and phosphorylation of the CCAAT enhancer-binding protein beta (C/EBP beta), which is one of the key transcriptional regulatory factors for IL-1 beta transcription. These results suggest that 1,25(OH)(2)D-3 may function as a proinflammatory molecule in inflammatory macrophages. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | VITAMIN-D | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | GENE | - |
dc.subject | EXPRESSION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | INHIBITION | - |
dc.subject | MATURATION | - |
dc.subject | INDUCTION | - |
dc.subject | MECHANISM | - |
dc.title | Upregulation of interleukin-1 beta production by 1,25-Dihydroxyvitamin D-3 in activated human macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Sohn, Jeongwon | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.identifier.doi | 10.1007/s11033-010-0348-z | - |
dc.identifier.scopusid | 2-s2.0-79951576610 | - |
dc.identifier.wosid | 000286941400096 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.38, no.3, pp.2193 - 2201 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 38 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 2193 | - |
dc.citation.endPage | 2201 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | 1,25-Dihydroxyvitamin D-3 | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Inflammation | - |
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