Identification and characterization of RNF2 response elements in human kidney cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Dongwon | - |
dc.contributor.author | Kang, Seongman | - |
dc.date.accessioned | 2021-09-07T14:45:58Z | - |
dc.date.available | 2021-09-07T14:45:58Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113010 | - |
dc.description.abstract | RING finger protein 2 (RNF2) contains a conserved Nterminal RING finger domain and functions as an E3 ligase. As a member of the Polycomb group family of proteins, RNF2 also represses a number of genes involved in development, differentiation, malignant transformation and cell cycle. Herein, using chromatin immunoprecipitation cloning, 33 RNF2-responding loci were identified in the genome of HEK293 human kidney cells. Luciferase reporter assays showed that among them, 26 and 2 loci acted as a repressor and an activator, respectively. RNA interference revealed that the identified RNF2-responding sequences regulated the transcriptional activity of nearby promoters. This study may contribute to elucidating the mechanism underlying RNF2-mediated transcriptional regulation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | POLYCOMB GROUP PROTEINS | - |
dc.subject | EPIGENETIC REGULATION | - |
dc.subject | CELLULAR MEMORY | - |
dc.subject | HISTONE H2A | - |
dc.subject | INTERACTS | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | EXPRESSION | - |
dc.subject | COMPLEXES | - |
dc.subject | GENOME | - |
dc.title | Identification and characterization of RNF2 response elements in human kidney cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seongman | - |
dc.identifier.doi | 10.1007/s10059-011-0033-7 | - |
dc.identifier.scopusid | 2-s2.0-79959936616 | - |
dc.identifier.wosid | 000288805400007 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.31, no.3, pp.247 - 253 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 31 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 253 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | POLYCOMB GROUP PROTEINS | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
dc.subject.keywordPlus | CELLULAR MEMORY | - |
dc.subject.keywordPlus | HISTONE H2A | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordAuthor | PcG complex | - |
dc.subject.keywordAuthor | RNF2 | - |
dc.subject.keywordAuthor | RNF2-responding loci | - |
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