Enzyme-catalyzed resolution of racemate using enzyme functionalized silica nanoparticles in the presence of surfactants
DC Field | Value | Language |
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dc.contributor.author | Song, Yoon Seok | - |
dc.contributor.author | Lee, Hee Uk | - |
dc.contributor.author | Lee, Jong Ho | - |
dc.contributor.author | Park, Chulhwan | - |
dc.contributor.author | Kim, Seung Wook | - |
dc.date.accessioned | 2021-09-07T14:49:42Z | - |
dc.date.available | 2021-09-07T14:49:42Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 1359-5113 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113031 | - |
dc.description.abstract | The enzyme-catalyzed resolution of racemic naproxen 2,2,2-trifluoroethyl thioester was performed by the immobilization of lipase on silica nanoparticles using a covalent bonding method. To increase the conversion and reaction rate of this resolution, we investigated the effect of non-ionic surfactants (M-SA 1025 and SM 20). The optimal reaction conditions such as temperature and loading amount of immobilized lipase were also determined. The addition of M-SA 1025 resulted in the increase in reaction rate (V-S), conversion (X-S) and enantioselectivity (E value) comparison with SM 20 and the control. The reaction performed in a mixture containing M-SA 1025 at 50 degrees C with 80 U/mL of immobilized lipase markedly improved the resolution of racemic naproxen 2,2,2-trifluoroethyl thioester compared to other conditions. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | NAPROXEN 2,2,2-TRIFLUOROETHYL THIOESTER | - |
dc.subject | CANDIDA-RUGOSA LIPASE | - |
dc.subject | KINETIC RESOLUTION | - |
dc.subject | ENANTIOSELECTIVE ESTERIFICATION | - |
dc.subject | HYDROLYSIS | - |
dc.subject | ESTER | - |
dc.subject | OPTIMIZATION | - |
dc.subject | PERFORMANCE | - |
dc.subject | ACID | - |
dc.title | Enzyme-catalyzed resolution of racemate using enzyme functionalized silica nanoparticles in the presence of surfactants | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seung Wook | - |
dc.identifier.doi | 10.1016/j.procbio.2010.12.010 | - |
dc.identifier.scopusid | 2-s2.0-79951511778 | - |
dc.identifier.wosid | 000288419900033 | - |
dc.identifier.bibliographicCitation | PROCESS BIOCHEMISTRY, v.46, no.3, pp.817 - 820 | - |
dc.relation.isPartOf | PROCESS BIOCHEMISTRY | - |
dc.citation.title | PROCESS BIOCHEMISTRY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 817 | - |
dc.citation.endPage | 820 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | NAPROXEN 2,2,2-TRIFLUOROETHYL THIOESTER | - |
dc.subject.keywordPlus | CANDIDA-RUGOSA LIPASE | - |
dc.subject.keywordPlus | KINETIC RESOLUTION | - |
dc.subject.keywordPlus | ENANTIOSELECTIVE ESTERIFICATION | - |
dc.subject.keywordPlus | HYDROLYSIS | - |
dc.subject.keywordPlus | ESTER | - |
dc.subject.keywordPlus | OPTIMIZATION | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Lipase | - |
dc.subject.keywordAuthor | Resolution | - |
dc.subject.keywordAuthor | Naproxen | - |
dc.subject.keywordAuthor | Surfactant | - |
dc.subject.keywordAuthor | Silica nanoparticle | - |
dc.subject.keywordAuthor | Immobilization | - |
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