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Utilization of glycerol as cysteine and carbon sources for cephalosporin C production by Acremonium chrysogenum M35 in methionine-unsupplemented culture

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dc.contributor.authorShin, Hyun Yong-
dc.contributor.authorLee, Jin Young-
dc.contributor.authorPark, Chulhwan-
dc.contributor.authorKim, Seung Wook-
dc.date.accessioned2021-09-07T14:59:32Z-
dc.date.available2021-09-07T14:59:32Z-
dc.date.created2021-06-14-
dc.date.issued2011-02-20-
dc.identifier.issn0168-1656-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/113050-
dc.description.abstractIn this study, the role of glycerol in cephalosporin C production was evaluated in Acremonium chrysogenum M35. Methionine-unsupplemented culture with glycerol stimulated cephalosporin C production in A. chrysogenum M35 by up to 10-fold while increasing the amount of cysteine. Glycerol caused the upregulation of isopenicillin N-CoA epimerase (cefD2) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthase (pcbAB) transcription in exponential phase. These results indicate that glycerol without methionine effectively enhanced cephalosporin C production via stimulation of cysteine and valine in A. chrysogemun M35. (C) 2011 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectCYSTATHIONINE-GAMMA-LYASE-
dc.subjectPENICILLIN-N-
dc.subjectISOPENICILLIN-N-
dc.subjectFATTY-ACIDS-
dc.subjectMECB GENE-
dc.subjectBIOSYNTHESIS-
dc.subjectVALINE-
dc.subjectSTIMULATION-
dc.subjectSYNTHETASE-
dc.subjectCONVERSION-
dc.titleUtilization of glycerol as cysteine and carbon sources for cephalosporin C production by Acremonium chrysogenum M35 in methionine-unsupplemented culture-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Seung Wook-
dc.identifier.doi10.1016/j.jbiotec.2010.12.021-
dc.identifier.scopusid2-s2.0-79951556560-
dc.identifier.wosid000288057600010-
dc.identifier.bibliographicCitationJOURNAL OF BIOTECHNOLOGY, v.151, no.4, pp.363 - 368-
dc.relation.isPartOfJOURNAL OF BIOTECHNOLOGY-
dc.citation.titleJOURNAL OF BIOTECHNOLOGY-
dc.citation.volume151-
dc.citation.number4-
dc.citation.startPage363-
dc.citation.endPage368-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.subject.keywordPlusCYSTATHIONINE-GAMMA-LYASE-
dc.subject.keywordPlusPENICILLIN-N-
dc.subject.keywordPlusISOPENICILLIN-N-
dc.subject.keywordPlusFATTY-ACIDS-
dc.subject.keywordPlusMECB GENE-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusVALINE-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordPlusSYNTHETASE-
dc.subject.keywordPlusCONVERSION-
dc.subject.keywordAuthorCysteine-
dc.subject.keywordAuthorAcremonium chrysogenum-
dc.subject.keywordAuthorMethionine-
dc.subject.keywordAuthorCephalosporin C-
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