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Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

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dc.contributor.authorHong, Seong Su-
dc.contributor.authorLee, Seon A.-
dc.contributor.authorKim, Nahyun-
dc.contributor.authorHwang, Ji Sang-
dc.contributor.authorHan, Xiang Hua-
dc.contributor.authorLee, Mi Kyeong-
dc.contributor.authorJung, Jae Kyung-
dc.contributor.authorHong, Jin Tae-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorLee, Dongho-
dc.contributor.authorHwang, Bang Yeon-
dc.date.accessioned2021-09-07T15:09:57Z-
dc.date.available2021-09-07T15:09:57Z-
dc.date.created2021-06-14-
dc.date.issued2011-02-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/113067-
dc.description.abstractA new pyrrolidinone diterpenoid, excisusin F(1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 mu M, respectively. (C) 2011 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectENT-KAURENE DITERPENOIDS-
dc.subjectKAPPA-B ACTIVATION-
dc.subjectKAURANE DITERPENOIDS-
dc.subjectNO PRODUCTION-
dc.subjectCONSTITUENTS-
dc.subjectLEAVES-
dc.subjectMEGASTIGMANE-
dc.subjectRUBESCENS-
dc.subjectJAPONICUS-
dc.titlePyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1016/j.bmcl.2010.11.095-
dc.identifier.scopusid2-s2.0-79851508272-
dc.identifier.wosid000286972400041-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.4, pp.1279 - 1281-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume21-
dc.citation.number4-
dc.citation.startPage1279-
dc.citation.endPage1281-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusENT-KAURENE DITERPENOIDS-
dc.subject.keywordPlusKAPPA-B ACTIVATION-
dc.subject.keywordPlusKAURANE DITERPENOIDS-
dc.subject.keywordPlusNO PRODUCTION-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusLEAVES-
dc.subject.keywordPlusMEGASTIGMANE-
dc.subject.keywordPlusRUBESCENS-
dc.subject.keywordPlusJAPONICUS-
dc.subject.keywordAuthorIsodon excisus-
dc.subject.keywordAuthorLamiaceae-
dc.subject.keywordAuthorPyrrolidinone diterpenoid-
dc.subject.keywordAuthorNitric oxide inhibitor-
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