Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010
- Authors
- Gu, Se Hun; Kang, Hae Ji; Baek, Luck Ju; Noh, Ji Yun; Kim, Heung-Chul; Klein, Terry A.; Yanagihara, Richard; Song, Jin-Won
- Issue Date
- 8-2월-2011
- Publisher
- BMC
- Citation
- VIROLOGY JOURNAL, v.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- VIROLOGY JOURNAL
- Volume
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113081
- DOI
- 10.1186/1743-422X-8-56
- ISSN
- 1743-422X
- Abstract
- Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M-and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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