Evaluation of a urinary test as a diagnostic tool of a nonprogressive pregnancy
- Authors
- Mazouz, Silhem; Lee, Jae Kwan; Fernandez, Herve
- Issue Date
- 2월-2011
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Abnormal pregnancy; ectopic pregnancy; miscarriage; hCG; intact hCG; free beta-hCG; urine test
- Citation
- FERTILITY AND STERILITY, v.95, no.2, pp.783 - 786
- Indexed
- SCIE
SCOPUS
- Journal Title
- FERTILITY AND STERILITY
- Volume
- 95
- Number
- 2
- Start Page
- 783
- End Page
- 786
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113116
- DOI
- 10.1016/j.fertnstert.2010.08.003
- ISSN
- 0015-0282
- Abstract
- Objective: To evaluate the performance of a one-step test detecting intact hCG and free beta-hCG isoforms in the urine of pregnant women to diagnose an abnormal pregnancy. Design: Prospective study. Setting: Emergency gynecology departments in teaching hospitals. Patient(s): Five hundred twenty-six patients were enrolled, 272 who were not pregnant and 254 who were pregnant. Intervention(s) and Main Outcome Measure(s): Semiquantitative determination of intact urinary hCG of supposedly not pregnant and pregnant women with vaginal bleeding and/or vaginal pain between 5 and 8 weeks of amenorrhea. Result(s): The sensitivity and specificity of the urine test for diagnosing nonpregnancy were, respectively, 100% (252/252) and 100% (272/272). The sensitivity and specificity of the urine test for diagnosing ectopic pregnancy (EP) were, respectively, 97% (32/33) and 83% (142/171). The negative predictive value is 99.3% (142/143). The sensitivity and specificity or the urine test for diagnosing miscarriage were, respectively, 89.6% (43/48) and 83% (142/171). The negative predictive value is 96.6% (142/147). Conclusion(s): Abnormal pregnancy, such as an EP or a miscarriage, can be rapidly detected with the one-step test for intact hCG and free b-hCG isoforms. If ultrasound cannot confirm the localization and/or evolution of a pregnancy, using this test reduces medical supervision and repeated quantification of hCG. (Fertil Steril(R) 2011;95:783-6. (C) 2011 by American Society for Reproductive Medicine.)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.