IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling
DC Field | Value | Language |
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dc.contributor.author | Lee, Suk Jun | - |
dc.contributor.author | Lee, Eun Ju | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Choi, Inho | - |
dc.contributor.author | Lee, Dong-Mok | - |
dc.contributor.author | Lee, Hyun-Jeong | - |
dc.contributor.author | Yoon, Duhak | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2021-09-07T15:35:23Z | - |
dc.date.available | 2021-09-07T15:35:23Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113144 | - |
dc.description.abstract | Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein beta (C/EPB beta) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor gamma (PPAR gamma). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | 3T3-L1 ADIPOCYTES | - |
dc.subject | INFLAMMATION | - |
dc.subject | OBESITY | - |
dc.subject | CYTOKINES | - |
dc.subject | FAMILY | - |
dc.title | IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
dc.identifier.doi | 10.1007/s10529-010-0440-4 | - |
dc.identifier.scopusid | 2-s2.0-78651452954 | - |
dc.identifier.wosid | 000286198700004 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY LETTERS, v.33, no.2, pp.229 - 235 | - |
dc.relation.isPartOf | BIOTECHNOLOGY LETTERS | - |
dc.citation.title | BIOTECHNOLOGY LETTERS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 229 | - |
dc.citation.endPage | 235 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Adipocyte | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Myoblast | - |
dc.subject.keywordAuthor | Transdifferentiation | - |
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