Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Effects of Benzo(a)pyrene on the Expression of Heat Shock Proteins, Pro-inflammatory Cytokines and Antioxidant Enzymes in Hepatic Tumors Induced by Rat Hepatoma N1-S1 Cells

Authors
Zheng, ZhiPark, So-YoungLee, MinPhark, SoheeWon, Nam HeeKang, Hyung-SikSul, Donggeun
Issue Date
2월-2011
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Liver Neoplasms; N1-S1 Rat Hepatoma Cells; Benzo(a)pyrene; Heat-Shock Proteins; Oxidative Stress; Cytokines
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.2, pp.222 - 230
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
26
Number
2
Start Page
222
End Page
230
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/113205
DOI
10.3346/jkms.2011.26.2.222
ISSN
1011-8934
Abstract
Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat. BaP causes harmful oxidative effects on cell development, growth and survival through an increase in membrane lipid peroxidation, oxidative DNA damage and mutagenesis. Therefore, the present study was conducted to evaluate the synergistic effects of BaP on oxidative stress in hepatic tumors. In this study, we established a hepatic tumor model by injecting rat hepatoma N1-S1 cells into healthy rats. Changes in the abundance of heat shock proteins (HSPs), antioxidant enzymes and pro-inflammatory cytokines were then investigated by western blot analysis. In addition, we examined changes in oxidative stress levels. Injection of N1-S1 cells or concomitant injection of BaP and N1-S1 cells resulted in the formation of hepatic tumors at the injection site. Evaluation of rat plasma reveals that hepatic tumors induced by BaP and N1-S1 cells expresses higher levels of Hsp27, superoxide dismutase (SOD), and tumor necrosis factor-alpha (INF-alpha) when compared to those induced by N1-S1 cells only. The collective results of this study suggest that BaP exerts synergistic effects on the expression of HSP, cytokines and antioxidant enzymes in hepatic tumors induced by rat hepatoma N1-S1 cells.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles
Graduate School > Department of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Sul, Dong Geun photo

Sul, Dong Geun
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE