Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3 beta signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Jun, Hyoung-Oh | - |
dc.contributor.author | Kim, Dong-hun | - |
dc.contributor.author | Lee, Sae-Won | - |
dc.contributor.author | Lee, Hye Shin | - |
dc.contributor.author | Seo, Ji Hae | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Min, Bon Hong | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.date.accessioned | 2021-09-07T15:58:09Z | - |
dc.date.available | 2021-09-07T15:58:09Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113242 | - |
dc.description.abstract | Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin protects H9c2 cardiomyocytes from H2O2-induced apoptosis by triggering the activation of Akt and GSK-3 beta. Treatment with H2O2 induces apoptosis of H9c2 cells by promoting caspase cleavage and cytochrome c release from mitochondria. However, co-treatment with clusterin reverses the induction of apoptotic signaling by H2O2, thereby recovers cell viability. The protective effect of clusterin on H2O2-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-3 beta. In addition, the protective effect of clusterin is independednt on its receptor megalin, because inhibition of megalin has no effect on clusturin-mediated Akt/GSK-3 beta phosphoylation and H9c2 cell viability. Collectively, these results suggest that clusterin has a role protecting cardiomyocytes from oxidative stress and the Akt/GSK-3 beta signaling mediates anti-apoptotic effect of clusterin. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | APOLIPOPROTEIN-J/CLUSTERIN | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | REPERFUSION INJURY | - |
dc.subject | CELL-DEATH | - |
dc.subject | ISCHEMIA | - |
dc.subject | PROTEINS | - |
dc.subject | GLYCOPROTEIN | - |
dc.subject | INDUCTION | - |
dc.subject | SURVIVAL | - |
dc.subject | RECEPTOR | - |
dc.title | Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3 beta signaling pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Bon Hong | - |
dc.identifier.doi | 10.3858/emm.2011.43.1.006 | - |
dc.identifier.scopusid | 2-s2.0-79251620191 | - |
dc.identifier.wosid | 000286867900007 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.43, no.1, pp.53 - 61 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 61 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001521101 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-J/CLUSTERIN | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | clusterin | - |
dc.subject.keywordAuthor | glycogen synthase kinase 3 beta | - |
dc.subject.keywordAuthor | myocytes, cardiac | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | proto-oncogene proteins c-akt | - |
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