Visfatin Induces Sickness Responses in the Brain
DC Field | Value | Language |
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dc.contributor.author | Park, Byong Seo | - |
dc.contributor.author | Jin, Sung Ho | - |
dc.contributor.author | Park, Joong Jean | - |
dc.contributor.author | Park, Jeong Woo | - |
dc.contributor.author | Namgoong, Il Seong | - |
dc.contributor.author | Kim, Young Il | - |
dc.contributor.author | Lee, Byung Ju | - |
dc.contributor.author | Kim, Jae Geun | - |
dc.date.accessioned | 2021-09-07T16:01:05Z | - |
dc.date.available | 2021-09-07T16:01:05Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01-20 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113258 | - |
dc.description.abstract | Background/Objective: Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in sepsis and cancer as well as in obesity. Here we report a pro-inflammatory role of visfatin in the brain, to mediate sickness responses including anorexia, hyperthermia and hypoactivity. Methodology: Rats were intracerebroventricularly (ICV) injected with visfatin, and changes in food intake, body weight, body temperature and locomotor activity were monitored. Real-time PCR was applied to determine the expressions of proinflammatory cytokines, proopiomelanocortin (POMC) and prostaglandin-synthesizing enzymes in their brain. To determine the roles of cyclooxygenase (COX) and melanocortin in the visfatin action, rats were ICV-injected with visfatin with or without SHU9119, a melanocortin receptor antagonist, or indomethacin, a COX inhibitor, and their sickness behaviors were evaluated. Principal Findings: Administration of visfatin decreased food intake, body weight and locomotor activity and increased body temperature. Visfatin evoked significant increases in the levels of pro-inflammatory cytokines, prostaglandin-synthesizing enzymes and POMC, an anorexigenic neuropeptide. Indomethacin attenuated the effects of visfatin on hyperthermia and hypoactivity, but not anorexia. Further, SHU9119 blocked visfatin-induced anorexia but did not affect hyperthermia or hypoactivity. Conclusions: Visfatin induced sickness responses via regulation of COX and the melanocortin pathway in the brain. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | COLONY-ENHANCING FACTOR | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | INFLAMMATION | - |
dc.subject | ANOREXIA | - |
dc.subject | BEHAVIOR | - |
dc.subject | OBESITY | - |
dc.subject | ADIPOCYTOKINE | - |
dc.subject | HYPOTHALAMUS | - |
dc.subject | MECHANISMS | - |
dc.subject | APPETITE | - |
dc.title | Visfatin Induces Sickness Responses in the Brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Joong Jean | - |
dc.identifier.doi | 10.1371/journal.pone.0015981 | - |
dc.identifier.scopusid | 2-s2.0-79251645369 | - |
dc.identifier.wosid | 000286522200020 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.6, no.1 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | COLONY-ENHANCING FACTOR | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANOREXIA | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ADIPOCYTOKINE | - |
dc.subject.keywordPlus | HYPOTHALAMUS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APPETITE | - |
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