Size-controllable quartz nanostructure for signal enhancement of DNA chip
- Authors
- Kim, Jung Suk; Cho, Jae Bum; Park, Bo Gi; Lee, Wonbae; Lee, Kyu Back; Oh, Min-Kyu
- Issue Date
- 15-1월-2011
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Keywords
- Nanostructured quartz; Nanopillar; DNA chip; DNA sensor
- Citation
- BIOSENSORS & BIOELECTRONICS, v.26, no.5, pp.2085 - 2089
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSENSORS & BIOELECTRONICS
- Volume
- 26
- Number
- 5
- Start Page
- 2085
- End Page
- 2089
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113270
- DOI
- 10.1016/j.bios.2010.09.010
- ISSN
- 0956-5663
- Abstract
- A mask-free, cost-effective dry-etching method for the fabrication of height- and spacing-controlled, pillar-like nanostructures was established in order to detect DNA molecules. The height and spacing of the quartz nanostructure were regulated by successive O-2 and CF4 reactive ion etching times. The height and spacing of the nanostructures were tuned between 118 and 269 nm and between 107 and 161 nm, respectively. Probe DNA was immobilized on the structure and hybridized with fluorescently-labeled target DNA. Increases in the height and spacing of the nanopillar structure positively correlated with the fluorescence intensity of bound DNA. Usage of the nanostructure increased the DNA detection limit by up to 100-fold. (C) 2010 Elsevier B.V. All rights reserved.
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- Appears in
Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
- College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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