Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, Ming | - |
dc.contributor.author | Chen, Xiguang | - |
dc.contributor.author | Park, Hyunjin | - |
dc.date.accessioned | 2021-09-07T16:15:32Z | - |
dc.date.available | 2021-09-07T16:15:32Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01-10 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113280 | - |
dc.description.abstract | Hyaluronic acid (HA) was modified Into an amphiphile through esterification between the carboxyl and hydroxyl moieties on glycerol-a-monostearate (GMS) The conjugation was verified via FT/IR and H-1 NMR Ultrasonification and solvent evaporation were used to prepare a fine oil/water/surfactant (O/W/S) nanoemulsion consisting of methylene chloride as the oil phase (0) HA water solution (W) and nonionic Tween-80 and Span-20 as surfactant (S) The optimal ratio of the disperse phase was screened in nanoemulsion formed without HA-GMS Tween-80 and Span-20 at the required hydrophilic-lipophilic balance (HLB) of 125 and a ratio of O/S (ROS) 01 60 which accounted for 5% (w/w) in the emulsion system was determined to be the optimal disperse phase ratio giving rise to the smallest droplet size (39 7 nm) and lower protein dispersibility (0341) The smallest droplet size of the HA-GMS nanoemulsion was 42 0 nm with contraction to 38 9 nm evident after 96 h storage Higher degree of substitution or lower molecular weight was favorable for the formation of smaller emulsified droplets Nanoemulsions were characterized morphologically by electronic microscopy (C) 2010 Elsevier Ltd All rights reserved | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | NANOPARTICLES | - |
dc.subject | DELIVERY | - |
dc.subject | SIZE | - |
dc.subject | STABILITY | - |
dc.subject | MECHANISM | - |
dc.title | Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hyunjin | - |
dc.identifier.doi | 10.1016/j.carbpol.2010.08.001 | - |
dc.identifier.scopusid | 2-s2.0-78349310679 | - |
dc.identifier.wosid | 000285437000019 | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.83, no.2, pp.462 - 469 | - |
dc.relation.isPartOf | CARBOHYDRATE POLYMERS | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 83 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 462 | - |
dc.citation.endPage | 469 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Monostearin | - |
dc.subject.keywordAuthor | Nanoemulsion | - |
dc.subject.keywordAuthor | Solvent evaporation | - |
dc.subject.keywordAuthor | Methylene chloride | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.