Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wei, Chun Hua | - |
dc.contributor.author | Lee, Eung Suk | - |
dc.contributor.author | Jeon, Jeong Yi | - |
dc.contributor.author | Heo, Yong-Seok | - |
dc.contributor.author | Kim, Seung Jun | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Kim, Kyung Hyun | - |
dc.contributor.author | Hong, Hyo Jeong | - |
dc.contributor.author | Ryu, Seong Eon | - |
dc.date.accessioned | 2021-09-07T16:18:22Z | - |
dc.date.available | 2021-09-07T16:18:22Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01-03 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113290 | - |
dc.description.abstract | The L1CAM antibody A10-A3 efficiently reduces tumor growth in a nude mouse model. Here, we describe the crystal structure of the Fab fragment of A10-A3 determined at 2.0 angstrom resolution. The A10-A3 antibody H3 loop reveals a characteristic arrangement of exposed aromatic residues that may play an important role in antigen binding. A structure model of the complex between L1CAM Ig1-4 and A10-A3 Fab indicates that the Fab binds to three small loops outside Ig1 and a residue between Ig1 and Ig2, consistent with an epitope mapping result. The data presented here should contribute to the design of high-affinity antibody for therapeutic purposes as well as to the understanding of neural cell remodeling and cancer progression mechanism mediated by L1CAM. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | PROTEIN | - |
dc.subject | GROWTH | - |
dc.subject | IMMUNOGLOBULINS | - |
dc.subject | INHIBITION | - |
dc.subject | SUGGESTS | - |
dc.subject | SYSTEM | - |
dc.subject | FAMILY | - |
dc.subject | CANCER | - |
dc.subject | MODEL | - |
dc.title | Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hyun | - |
dc.identifier.doi | 10.1016/j.febslet.2010.11.028 | - |
dc.identifier.scopusid | 2-s2.0-78650874809 | - |
dc.identifier.wosid | 000285921500026 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.1, pp.153 - 158 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 158 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | IMMUNOGLOBULINS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SUGGESTS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Crystal structure | - |
dc.subject.keywordAuthor | Antibody | - |
dc.subject.keywordAuthor | A10-A3 | - |
dc.subject.keywordAuthor | L1CAM | - |
dc.subject.keywordAuthor | Cancer | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.